SWC4_USTMA
ID SWC4_USTMA Reviewed; 615 AA.
AC Q4PG15; A0A0D1CD44;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=SWR1-complex protein 4;
GN Name=SWC4; ORFNames=UMAG_00948;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC involved in DNA repair (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC NuA4 histone acetyltransferase complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SWC4 family. {ECO:0000305}.
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DR EMBL; CM003141; KIS71032.1; -; Genomic_DNA.
DR RefSeq; XP_011386947.1; XM_011388645.1.
DR AlphaFoldDB; Q4PG15; -.
DR SMR; Q4PG15; -.
DR STRING; 5270.UM00948P0; -.
DR EnsemblFungi; KIS71032; KIS71032; UMAG_00948.
DR GeneID; 23562103; -.
DR KEGG; uma:UMAG_00948; -.
DR VEuPathDB; FungiDB:UMAG_00948; -.
DR eggNOG; KOG2656; Eukaryota.
DR HOGENOM; CLU_018539_4_1_1; -.
DR InParanoid; Q4PG15; -.
DR OMA; DEMQCIV; -.
DR OrthoDB; 918816at2759; -.
DR Proteomes; UP000000561; Chromosome 2.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR032563; DAMP1_SANT-like.
DR InterPro; IPR027109; Swc4/Dmap1.
DR PANTHER; PTHR12855; PTHR12855; 1.
DR Pfam; PF16282; SANT_DAMP1_like; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..615
FT /note="SWR1-complex protein 4"
FT /id="PRO_0000076345"
FT DOMAIN 185..256
FT /note="SANT"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 615 AA; 66954 MW; 9C1A698335348C10 CRC64;
MTSNDVRDIL SLPERPASQP SSSAQASGSS SRNRKSSGSN NPHPSSAASA SRPKPKYDGM
TRELFALLGD NAPSLAMTHG LDAEGKPVMG LGGLFKPKFK RRKEKVRQWR WTPFLNSARD
DTQIDDDVPE INHGLILHHW APARSFSTTA ADGISAEDAD IDTKYQYAAF NTTSGVYSYS
NDEYIQHLRD DDWTKEETDY LMELCTAYDL RFVVIHDRYD WAAAQASFLA GSTSAVPQPV
KERSMEDLKV RYYAICRRLI RSRISTDDVE TRQMLLSTYA FDKQREVERK KAVARLYTRT
PEQLAEEEAL YVEIRRIEQN EAKYASEREE LLRLLGGWES LPSSSPHAVA AAGSGIASLL
GAEEDSTAKG RAGSANKKRK LQQIEDNGTP GADDAGSSTG ATAAATSRPS ANLTSKQRAE
LRQAQFDEMQ CIVRFASNAN ATTDASAGGI AGPAAVSAAS SSTRPPYAYL VGTASTLPAV
TSNPANPTSG HGVYLRSSRM LAPRPNLVLR TTQVLSESDP PVGPRLIFPT AKNVEKWENL
IGAVTTGLEM RKQLERVNAE LRIAKQRIAA ALHPNRMADK SEASAEAVES RSAAPTENSI
AATTSTHAQI TIKTE
