ID   SWC5_ASPFU              Reviewed;         359 AA.
AC   Q4WRE2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=SWR1-complex protein 5;
GN   Name=swc5; ORFNames=AFUA_1G16610;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC5 family. {ECO:0000305}.
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DR   EMBL; AAHF01000004; EAL90990.1; -; Genomic_DNA.
DR   RefSeq; XP_753028.1; XM_747935.1.
DR   AlphaFoldDB; Q4WRE2; -.
DR   SMR; Q4WRE2; -.
DR   STRING; 746128.CADAFUBP00001566; -.
DR   EnsemblFungi; EAL90990; EAL90990; AFUA_1G16610.
DR   GeneID; 3510054; -.
DR   KEGG; afm:AFUA_1G16610; -.
DR   VEuPathDB; FungiDB:Afu1g16610; -.
DR   eggNOG; KOG4776; Eukaryota.
DR   HOGENOM; CLU_062474_0_0_1; -.
DR   InParanoid; Q4WRE2; -.
DR   OMA; LDWAAYV; -.
DR   OrthoDB; 1372508at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR011421; BCNT-C.
DR   Pfam; PF07572; BCNT; 1.
DR   PROSITE; PS51279; BCNT_C; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..359
FT                   /note="SWR1-complex protein 5"
FT                   /id="PRO_0000212502"
FT   DOMAIN          282..359
FT                   /note="BCNT-C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00610"
FT   REGION          1..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..44
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  39638 MW;  3C6FAFA544EA40DB CRC64;
     MASEPAATVA DLDFDNEQYD SAEDEDFQLD PDQEDADLTG SDSDDEATEP AAKRRKTGPT
     KAATEDQELD SGDEAMIQKV KARKEGKQKG KKSQGTASDE DEDDVDFDDD DEGGPGGFVR
     TRAMRMRMQE ERKPLAKIDG ATVDVDAIWA QMNAPDSSAG ILPSQTQAKD ATPAKDENKN
     ADTAEEQVLS PDSKPQYKEE MVKIKRTYKF AGEVITEEKI VPKDSAEAKL FLAKGESVET
     VTDADVEHAA NAKDALKLRR PLRKISRFDP NPTGTIKKSW EKQPTAGITG QTENISGPKI
     NTVEKSRLDW AAYVDQAGIK DELKEHSKAK EGFLGRMDFL NRVVAKREEE RRNARLKGL