ID   SWC5_CANGA              Reviewed;         299 AA.
AC   Q6FML0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=SWR1-complex protein 5;
GN   Name=SWC5; OrderedLocusNames=CAGL0K07139g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC5 family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61495.1; -; Genomic_DNA.
DR   RefSeq; XP_448534.1; XM_448534.1.
DR   AlphaFoldDB; Q6FML0; -.
DR   SMR; Q6FML0; -.
DR   STRING; 5478.XP_448534.1; -.
DR   EnsemblFungi; CAG61495; CAG61495; CAGL0K07139g.
DR   GeneID; 2890393; -.
DR   KEGG; cgr:CAGL0K07139g; -.
DR   CGD; CAL0134731; CAGL0K07139g.
DR   VEuPathDB; FungiDB:CAGL0K07139g; -.
DR   eggNOG; KOG4776; Eukaryota.
DR   HOGENOM; CLU_062474_1_0_1; -.
DR   InParanoid; Q6FML0; -.
DR   OMA; LDWAAYV; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR   GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR   InterPro; IPR011421; BCNT-C.
DR   Pfam; PF07572; BCNT; 1.
DR   PROSITE; PS51279; BCNT_C; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..299
FT                   /note="SWR1-complex protein 5"
FT                   /id="PRO_0000212504"
FT   DOMAIN          216..293
FT                   /note="BCNT-C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00610"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..211
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   299 AA;  34290 MW;  A9048697765E3461 CRC64;
     MEETDIAKLS EEEYNEEEDE DFDPTKGTAV AGAEVSDGED DDEDDEDDSR VKDSYSHIVS
     ESGGLVKTRR ARQQEEEFKR KNKYEGIVEA AISEKVGSIW EDLKKESLSR LHNKENDSVI
     SESSKLKKDN HVAGEEMVTI ERVYKFAGET IREKKTVPIS SAEAVEYLNN LKFRKSTDQA
     GSTKRKLEEI DVKENNNTNE DTSESGIDRK KLRRPLKRPP FLEQIISGAL KPKLSTLEKS
     KLDWATYVDK EGINDELSAH NKDGYLAKQD FLNKVDSVKE NEYKELRRKE MMIRLQETK