ID   SWC5_NEUCR              Reviewed;         342 AA.
AC   Q7RYI3;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=SWR1-complex protein 5;
DE   AltName: Full=Chromatin-remodeling complex protein 2;
GN   Name=crc-2; Synonyms=swc5; ORFNames=NCU06491;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant H2A.Z leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWC5 family. {ECO:0000305}.
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DR   EMBL; CM002238; EAA27895.1; -; Genomic_DNA.
DR   RefSeq; XP_957131.1; XM_952038.2.
DR   AlphaFoldDB; Q7RYI3; -.
DR   STRING; 5141.EFNCRP00000006206; -.
DR   PRIDE; Q7RYI3; -.
DR   EnsemblFungi; EAA27895; EAA27895; NCU06491.
DR   GeneID; 3873269; -.
DR   KEGG; ncr:NCU06491; -.
DR   VEuPathDB; FungiDB:NCU06491; -.
DR   HOGENOM; CLU_062474_0_0_1; -.
DR   InParanoid; Q7RYI3; -.
DR   OMA; LDWAAYV; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   InterPro; IPR011421; BCNT-C.
DR   InterPro; IPR027124; Swc5/CFDP1/2.
DR   PANTHER; PTHR23227; PTHR23227; 1.
DR   Pfam; PF07572; BCNT; 1.
DR   PROSITE; PS51279; BCNT_C; 1.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..342
FT                   /note="SWR1-complex protein 5"
FT                   /id="PRO_0000212509"
FT   DOMAIN          260..341
FT                   /note="BCNT-C"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00610"
FT   REGION          1..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..44
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   342 AA;  37162 MW;  0D2F3714854BDFFD CRC64;
     MAPTLELLAE DYASEEDSDF APETAEAAGE SSISDDDDEE AGEDAEKAKP EKRKRAAIEE
     AEDAGYDNSG DEAIIKKGEK RQKKTKTKLA ADDEETGEGG LIKTRSQRAV EKEKRSTAAA
     SGPVTIDVDA LWAQMISEPV IPRTSTAKPD ESADPANCDI AKSSSQQPET AKAKDPDSDL
     IKIKRTYNFA GKVHTEEKLV ARDSAEAKLY LASLGENAPA DGETAAEDES SSAKRMPRKA
     FRSVFEPITD ANSAHRSDLN LSMASRLQAR EATGNKAKKL NTVEKSKMDW AVAVDKMGLK
     DELELAGKSK DSFAARQDFL ARSEMRREEE ARRARMAQAG KT