SWD1_SCHPO
ID SWD1_SCHPO Reviewed; 398 AA.
AC O42858;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Set1 complex component swd1;
DE Short=Set1C component swd1;
DE AltName: Full=COMPASS component swd1;
DE AltName: Full=Complex proteins associated with set1 protein swd1;
GN Name=swd1; ORFNames=SPAC23H3.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND COMPOSITION OF THE SET1 COMPLEX.
RX PubMed=12488447; DOI=10.1074/jbc.m209562200;
RA Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A.,
RA Stewart A.F.;
RT "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation
RT in budding and fission yeasts.";
RL J. Biol. Chem. 278:8487-8493(2003).
RN [3]
RP COMPOSITION OF THE SET1 COMPLEX.
RX PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
RA Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
RA Shevchenko A.;
RT "A comparative analysis of an orthologous proteomic environment in the
RT yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
RL Mol. Cell. Proteomics 3:125-132(2004).
CC -!- FUNCTION: The Set1 complex specifically methylates 'Lys-4' of histone
CC H3. {ECO:0000269|PubMed:12488447}.
CC -!- SUBUNIT: Component of the Set1 complex composed of ash2, sdc1, set1,
CC shg1, spp1, swd1, swd2 and swd3.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CU329670; CAB16241.2; -; Genomic_DNA.
DR PIR; T38298; T38298.
DR RefSeq; NP_593795.1; NM_001019224.2.
DR AlphaFoldDB; O42858; -.
DR SMR; O42858; -.
DR BioGRID; 278270; 281.
DR ELM; O42858; -.
DR STRING; 4896.SPAC23H3.05c.1; -.
DR iPTMnet; O42858; -.
DR SwissPalm; O42858; -.
DR MaxQB; O42858; -.
DR PaxDb; O42858; -.
DR EnsemblFungi; SPAC23H3.05c.1; SPAC23H3.05c.1:pep; SPAC23H3.05c.
DR GeneID; 2541776; -.
DR KEGG; spo:SPAC23H3.05c; -.
DR PomBase; SPAC23H3.05c; swd1.
DR VEuPathDB; FungiDB:SPAC23H3.05c; -.
DR eggNOG; KOG1273; Eukaryota.
DR HOGENOM; CLU_032142_0_0_1; -.
DR InParanoid; O42858; -.
DR OMA; DYEDDIM; -.
DR PhylomeDB; O42858; -.
DR Reactome; R-SPO-8951664; Neddylation.
DR PRO; PR:O42858; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IC:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IDA:PomBase.
DR GO; GO:0031507; P:heterochromatin assembly; IC:PomBase.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR037850; RBBP5/Swd1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR42968:SF26; PTHR42968:SF26; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..398
FT /note="Set1 complex component swd1"
FT /id="PRO_0000051250"
FT REPEAT 22..61
FT /note="WD 1"
FT REPEAT 64..103
FT /note="WD 2"
FT REPEAT 162..202
FT /note="WD 3"
FT REPEAT 247..295
FT /note="WD 4"
FT REPEAT 296..336
FT /note="WD 5"
SQ SEQUENCE 398 AA; 45184 MW; 1EAFB611790AA5D6 CRC64;
MNLELLDPFS IPDYPEALTT TLKHGHATSI RFSTNGYHLA SGLVNGSVVI WDLSTFSVSR
VLTGHTRAIQ SVCWSSCDRF LLTASRDWKC ILWDLRDGSI VYQVVLSAPV WSASLHPHKI
NTFVASLLDE SPQLIIVDDG IPKHKYLPTN PDIDENYSDR RNRSKHVTLV SFFHPSGEYI
LSGTSKGWFH VIDASTTKIR SSHRITSQSI KQIRLSFCKR FLIFNSTDRV IRTVSIQDLD
NPEVEHKFQD VVNRLQWNSC GFSQTGEFVF ATTYQMAHAI YVWERGMGSL VKILEGPKEE
LVDVDWHPVF PCVASVGLDS GSIYIWAVEQ KESWSAFAPD FQELEENIEY EEPEDEFDIH
DETGKSEEEE YFTSVVKILP HDSSAEQPFV MPPTLSSS
