SWD1_YEAST
ID SWD1_YEAST Reviewed; 426 AA.
AC P39706; D6VPL8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 179.
DE RecName: Full=COMPASS component SWD1;
DE AltName: Full=Complex proteins associated with SET1 protein SWD1;
DE AltName: Full=Set1C component SWD1;
GN Name=SWD1; Synonyms=CPS50, SAF49; OrderedLocusNames=YAR003W;
GN ORFNames=FUN16;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=7941740; DOI=10.1002/yea.320100413;
RA Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B.,
RA Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.;
RT "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42
RT kbp SPO7-CENI-CDC15 region.";
RL Yeast 10:535-541(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND SUBUNIT.
RX PubMed=11742990; DOI=10.1093/emboj/20.24.7137;
RA Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M.,
RA Aasland R., Stewart A.F.;
RT "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and
RT methylates histone 3 lysine 4.";
RL EMBO J. 20:7137-7148(2001).
RN [5]
RP FUNCTION.
RX PubMed=11805083; DOI=10.1074/jbc.c200023200;
RA Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J.,
RA Johnston M., Shilatifard A.;
RT "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric
RT silencing of gene expression.";
RL J. Biol. Chem. 277:10753-10755(2002).
RN [6]
RP SUBUNIT.
RX PubMed=11687631; DOI=10.1073/pnas.231473398;
RA Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P.,
RA Johnston M., Greenblatt J.F., Shilatifard A.;
RT "COMPASS: a complex of proteins associated with a trithorax-related SET
RT domain protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=15282802; DOI=10.1002/yea.1133;
RA Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.;
RT "Localization of proteins that are coordinately expressed with Cln2 during
RT the cell cycle.";
RL Yeast 21:793-800(2004).
CC -!- FUNCTION: The COMPASS (Set1C) complex specifically mono-, di- and
CC trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays
CC a role in telomere length maintenance and transcription elongation
CC regulation. {ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11805083}.
CC -!- SUBUNIT: Component of the COMPASS (Set1C) complex which consists of
CC SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and
CC SWD3(1). {ECO:0000269|PubMed:11687631, ECO:0000269|PubMed:11742990}.
CC -!- INTERACTION:
CC P39706; P38123: SWD3; NbExp=6; IntAct=EBI-20737, EBI-20881;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15282802}.
CC Chromosome, telomere {ECO:0000269|PubMed:15282802}.
CC -!- MISCELLANEOUS: Present with 907 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; L22015; AAC04959.1; -; Genomic_DNA.
DR EMBL; BK006935; DAA06988.1; -; Genomic_DNA.
DR PIR; S40901; S40901.
DR RefSeq; NP_009403.1; NM_001178210.1.
DR PDB; 6BX3; EM; 4.30 A; B=2-413.
DR PDB; 6VEN; EM; 3.37 A; M=1-426.
DR PDBsum; 6BX3; -.
DR PDBsum; 6VEN; -.
DR AlphaFoldDB; P39706; -.
DR SMR; P39706; -.
DR BioGRID; 31792; 556.
DR ComplexPortal; CPX-1039; COMPASS complex.
DR DIP; DIP-1753N; -.
DR IntAct; P39706; 21.
DR MINT; P39706; -.
DR STRING; 4932.YAR003W; -.
DR MaxQB; P39706; -.
DR PaxDb; P39706; -.
DR PRIDE; P39706; -.
DR EnsemblFungi; YAR003W_mRNA; YAR003W; YAR003W.
DR GeneID; 851265; -.
DR KEGG; sce:YAR003W; -.
DR SGD; S000000064; SWD1.
DR VEuPathDB; FungiDB:YAR003W; -.
DR eggNOG; KOG1273; Eukaryota.
DR GeneTree; ENSGT00530000064100; -.
DR HOGENOM; CLU_032142_0_0_1; -.
DR InParanoid; P39706; -.
DR OMA; DYEDDIM; -.
DR BioCyc; YEAST:G3O-28868-MON; -.
DR Reactome; R-SCE-3214841; PKMTs methylate histone lysines.
DR PRO; PR:P39706; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; P39706; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IPI:SGD.
DR GO; GO:0051568; P:histone H3-K4 methylation; IDA:SGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:SGD.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:SGD.
DR GO; GO:0000723; P:telomere maintenance; IMP:SGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR037850; RBBP5/Swd1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44040; PTHR44040; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; Nucleus; Reference proteome; Repeat; Telomere;
KW WD repeat.
FT CHAIN 1..426
FT /note="COMPASS component SWD1"
FT /id="PRO_0000051251"
FT REPEAT 24..63
FT /note="WD 1"
FT REPEAT 70..109
FT /note="WD 2"
FT REPEAT 212..251
FT /note="WD 3"
FT REPEAT 264..307
FT /note="WD 4"
FT REPEAT 310..350
FT /note="WD 5"
FT STRAND 3..6
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 8..10
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 18..23
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 40..44
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 50..54
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 64..69
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 75..80
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 82..91
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 94..100
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 108..112
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 117..123
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 129..134
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 138..143
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 183..187
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 189..197
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 200..202
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 206..211
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 217..222
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 229..236
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 238..241
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 244..246
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 247..250
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 251..253
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 256..260
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 263..265
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 269..274
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 276..278
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 282..286
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 294..297
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 299..301
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 304..308
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 319..321
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 322..325
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 326..334
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 337..341
FT /evidence="ECO:0007829|PDB:6VEN"
FT HELIX 348..351
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 368..371
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 418..420
FT /evidence="ECO:0007829|PDB:6VEN"
SQ SEQUENCE 426 AA; 48655 MW; 90C389612AB66231 CRC64;
MNILLQDPFA VLKEHPEKLT HTIENPLRTE CLQFSPCGDY LALGCANGAL VIYDMDTFRP
ICVPGNMLGA HVRPITSIAW SPDGRLLLTS SRDWSIKLWD LSKPSKPLKE IRFDSPIWGC
QWLDAKRRLC VATIFEESDA YVIDFSNDPV ASLLSKSDEK QLSSTPDHGY VLVCTVHTKH
PNIIIVGTSK GWLDFYKFHS LYQTECIHSL KITSSNIKHL IVSQNGERLA INCSDRTIRQ
YEISIDDENS AVELTLEHKY QDVINKLQWN CILFSNNTAE YLVASTHGSS AHELYIWETT
SGTLVRVLEG AEEELIDINW DFYSMSIVSN GFESGNVYVW SVVIPPKWSA LAPDFEEVEE
NVDYLEKEDE FDEVDEAEQQ QGLEQEEEIA IDLRTREQYD VRGNNLLVER FTIPTDYTRI
IKMQSS
