SWD3_YEAST
ID SWD3_YEAST Reviewed; 315 AA.
AC P38123; D6VQH0;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=COMPASS component SWD3;
DE AltName: Full=Complex proteins associated with SET1 protein SWD3;
DE AltName: Full=Set1C component SWD3;
GN Name=SWD3; Synonyms=CPS30, SAF35; OrderedLocusNames=YBR175W;
GN ORFNames=YBR1237;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, AND SUBUNIT.
RX PubMed=11742990; DOI=10.1093/emboj/20.24.7137;
RA Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M.,
RA Aasland R., Stewart A.F.;
RT "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and
RT methylates histone 3 lysine 4.";
RL EMBO J. 20:7137-7148(2001).
RN [5]
RP FUNCTION.
RX PubMed=11805083; DOI=10.1074/jbc.c200023200;
RA Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J.,
RA Johnston M., Shilatifard A.;
RT "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric
RT silencing of gene expression.";
RL J. Biol. Chem. 277:10753-10755(2002).
RN [6]
RP SUBUNIT.
RX PubMed=11687631; DOI=10.1073/pnas.231473398;
RA Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P.,
RA Johnston M., Greenblatt J.F., Shilatifard A.;
RT "COMPASS: a complex of proteins associated with a trithorax-related SET
RT domain protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001).
CC -!- FUNCTION: The COMPASS (Set1C) complex specifically mono-, di- and
CC trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays
CC a role in telomere length maintenance and transcription elongation
CC regulation. {ECO:0000269|PubMed:11742990, ECO:0000269|PubMed:11805083}.
CC -!- SUBUNIT: Component of the COMPASS (Set1C) complex which consists of
CC SET1(2), BRE2(2), SPP1(2), SDC1(1), SHG1(1), SWD1(1), SWD2(1), and
CC SWD3(1). {ECO:0000269|PubMed:11687631, ECO:0000269|PubMed:11742990}.
CC -!- INTERACTION:
CC P38123; P39706: SWD1; NbExp=6; IntAct=EBI-20881, EBI-20737;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC {ECO:0000305}.
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DR EMBL; Z36043; CAA85136.1; -; Genomic_DNA.
DR EMBL; AY693212; AAT93231.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07290.1; -; Genomic_DNA.
DR PIR; S46046; S46046.
DR RefSeq; NP_009734.1; NM_001178523.1.
DR PDB; 6BX3; EM; 4.30 A; A=2-315.
DR PDB; 6VEN; EM; 3.37 A; L=1-315.
DR PDBsum; 6BX3; -.
DR PDBsum; 6VEN; -.
DR AlphaFoldDB; P38123; -.
DR SMR; P38123; -.
DR BioGRID; 32874; 329.
DR ComplexPortal; CPX-1039; COMPASS complex.
DR DIP; DIP-1754N; -.
DR IntAct; P38123; 32.
DR MINT; P38123; -.
DR STRING; 4932.YBR175W; -.
DR MaxQB; P38123; -.
DR PaxDb; P38123; -.
DR PRIDE; P38123; -.
DR EnsemblFungi; YBR175W_mRNA; YBR175W; YBR175W.
DR GeneID; 852472; -.
DR KEGG; sce:YBR175W; -.
DR SGD; S000000379; SWD3.
DR VEuPathDB; FungiDB:YBR175W; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_1_1; -.
DR InParanoid; P38123; -.
DR OMA; MWIVSGS; -.
DR BioCyc; YEAST:G3O-29122-MON; -.
DR Reactome; R-SCE-3214841; PKMTs methylate histone lysines.
DR Reactome; R-SCE-3214858; RMTs methylate histone arginines.
DR PRO; PR:P38123; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38123; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IPI:SGD.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IDA:SGD.
DR GO; GO:1903341; P:regulation of meiotic DNA double-strand break formation; IMP:SGD.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:SGD.
DR GO; GO:0000723; P:telomere maintenance; IMP:SGD.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; Nucleus; Reference proteome; Repeat; Telomere;
KW WD repeat.
FT CHAIN 1..315
FT /note="COMPASS component SWD3"
FT /id="PRO_0000051255"
FT REPEAT 53..93
FT /note="WD 1"
FT REPEAT 94..133
FT /note="WD 2"
FT REPEAT 136..178
FT /note="WD 3"
FT REPEAT 187..228
FT /note="WD 4"
FT REPEAT 238..278
FT /note="WD 5"
FT REPEAT 285..314
FT /note="WD 6"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 27..32
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 35..40
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 47..51
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 67..74
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 79..83
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 84..86
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 87..92
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 110..114
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 120..124
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 125..127
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 130..134
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 141..145
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 152..158
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 163..167
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 168..170
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 173..176
FT /evidence="ECO:0007829|PDB:6VEN"
FT HELIX 181..183
FT /evidence="ECO:0007829|PDB:6VEN"
FT HELIX 186..188
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 192..197
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 201..208
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 213..217
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 218..221
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 222..227
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 233..236
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 243..246
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 255..258
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 261..269
FT /evidence="ECO:0007829|PDB:6VEN"
FT TURN 270..272
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 275..280
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 290..296
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 299..307
FT /evidence="ECO:0007829|PDB:6VEN"
FT STRAND 309..312
FT /evidence="ECO:0007829|PDB:6VEN"
SQ SEQUENCE 315 AA; 34754 MW; E8E88C483D1CD776 CRC64;
MFQFVTPVGT QNGLKATCAK ISPDGQFLAI TQGLNILIYD INRRTVSQTL VTSHARPFSE
LCWSPDGQCI ATASDDFSVE IIHLSYGLLH TFIGHTAPVI SLTFNRKGNL LFTSSMDESI
KIWDTLNGSL MKTISAHSEA VVSVDVPMND SSILSSGSYD GLIRIFDAET GHCLKTLTYD
KDWKRENGVV PISQVKFSEN ARYLLVKSLD GVVKIWDCIG GCVVRTFQVQ PLEKGVLHHS
CGMDFLNPED GSTPLVISGY ENGDIYCWNS DTKSLLQLLD GSLYHHSSPV MSIHCFGNIM
CSLALNGDCC LWRWV
