ID   SWEET_VIBSN             Reviewed;          97 AA.
AC   F9RBV9;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Sugar transporter SemiSWEET;
GN   ORFNames=VIBRN418_06191 {ECO:0000312|EMBL:EGU34355.1};
OS   Vibrio sp. (strain N418).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=701176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N418 {ECO:0000312|EMBL:EGU34355.1};
RA   Strain E.A., Brown E., Allard M.W.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007744|PDB:4QND}
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS), SUBCELLULAR LOCATION, AND SUBUNIT.
RX   PubMed=25186729; DOI=10.1038/nature13670;
RA   Xu Y., Tao Y., Cheung L.S., Fan C., Chen L.Q., Xu S., Perry K.,
RA   Frommer W.B., Feng L.;
RT   "Structures of bacterial homologues of SWEET transporters in two distinct
RT   conformations.";
RL   Nature 515:448-452(2014).
CC   -!- FUNCTION: The homodimer mediates transmembrane sugar transport down a
CC       concentration gradient. Transport is probably effected by rocking-type
CC       movements, where a cargo-binding cavity opens first on one and then on
CC       the other side of the membrane. {ECO:0000250|UniProtKB:B0SR19}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:25186729}.
CC   -!- INTERACTION:
CC       F9RBV9; F9RBV9: VIBRN418_06191; NbExp=3; IntAct=EBI-16120089, EBI-16120089;
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000269|PubMed:25186729}.
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DR   EMBL; AFWD01000045; EGU34355.1; -; Genomic_DNA.
DR   RefSeq; WP_009733724.1; NZ_AFWD01000045.1.
DR   PDB; 4QND; X-ray; 1.70 A; A=1-97.
DR   PDBsum; 4QND; -.
DR   AlphaFoldDB; F9RBV9; -.
DR   SMR; F9RBV9; -.
DR   DIP; DIP-61075N; -.
DR   TCDB; 2.A.123.3.1; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR   EnsemblBacteria; EGU34355; EGU34355; VIBRN418_06191.
DR   eggNOG; ENOG5031BAK; Bacteria.
DR   Proteomes; UP000003627; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..97
FT                   /note="Sugar transporter SemiSWEET"
FT                   /id="PRO_0000432578"
FT   TRANSMEM        15..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000269|PubMed:25186729"
FT   TRANSMEM        44..65
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000269|PubMed:25186729"
FT   TRANSMEM        71..91
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000269|PubMed:25186729"
FT   DOMAIN          4..70
FT                   /note="PQ-loop"
FT                   /evidence="ECO:0000255"
FT   HELIX           2..11
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           12..14
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           15..25
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           27..34
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           38..43
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           46..65
FT                   /evidence="ECO:0007829|PDB:4QND"
FT   HELIX           69..93
FT                   /evidence="ECO:0007829|PDB:4QND"
SQ   SEQUENCE   97 AA;  10816 MW;  C696BCBE1A0D31AD CRC64;
     MALIERIGKA LEPLMLVMGL ISPLATMPQL YKLYVSHSEH ALGLSLTTWL LYSFIALLWT
     IYGIYHKNPT IWVGNCLGFL MYVAMVVGII AHTGGTY