SWET1_CAEEL
ID SWET1_CAEEL Reviewed; 299 AA.
AC O45102;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Sugar transporter SWEET1;
DE Short=CeSWEET1;
GN Name=swt-1; ORFNames=K02D7.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the membrane. {ECO:0000269|PubMed:21107422}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:21107422}. Cell membrane
CC {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; FO081176; CCD69688.1; -; Genomic_DNA.
DR PIR; T32982; T32982.
DR RefSeq; NP_499901.1; NM_067500.4.
DR AlphaFoldDB; O45102; -.
DR SMR; O45102; -.
DR STRING; 6239.K02D7.5; -.
DR TCDB; 2.A.123.1.10; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR PaxDb; O45102; -.
DR EnsemblMetazoa; K02D7.5.1; K02D7.5.1; WBGene00019300.
DR GeneID; 186875; -.
DR KEGG; cel:CELE_K02D7.5; -.
DR UCSC; K02D7.5; c. elegans.
DR CTD; 186875; -.
DR WormBase; K02D7.5; CE17998; WBGene00019300; swt-1.
DR eggNOG; KOG1623; Eukaryota.
DR GeneTree; ENSGT00390000007801; -.
DR HOGENOM; CLU_048643_3_1_1; -.
DR InParanoid; O45102; -.
DR OMA; KLWISIE; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; O45102; -.
DR PRO; PR:O45102; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00019300; Expressed in larva and 3 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; ISS:WormBase.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 3: Inferred from homology;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..299
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345125"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 7..91
FT /note="MtN3/slv 1"
FT DOMAIN 121..205
FT /note="MtN3/slv 2"
FT REGION 230..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 299 AA; 32696 MW; 84400109B695A3A2 CRC64;
MLEVVLQVLS ISAITTTIAL FFCGIPICMQ IRRQGAVGDI SGVPFLMGVL GGSFWLRYGL
LKMDYVMIIV NVVGVACMAF YCVFFLIYSL PKKTFTCQLI LVTSTIGGMV LWIALKPNLD
YLGVICMTFN IMNFGAPLAG LGVVLKNREV STLPLPMCVA NFLVSSQWCL YGNLVSDIYI
IIPNGIGMFL AIVQLALFVV LPIRENEKSP LEKLASWFTG RDSKVKDLER GDCIVSSPPS
SPQKVPNETR SDVEDKFDKL MAETSSTIPS DSRRGSMGSP PSYKSRSSSD PDLSSIQSP
