ID   SWET1_DANRE             Reviewed;         219 AA.
AC   Q5EB14;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Sugar transporter SWEET1;
DE   AltName: Full=RAG1-activating protein 1;
DE   AltName: Full=Solute carrier family 50 member 1;
GN   Name=slc50a1; Synonyms=rag1ap1; ORFNames=zgc:113092;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates sugar transport across membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH90168.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC090168; AAH90168.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001012515.1; NM_001012497.1.
DR   AlphaFoldDB; Q5EB14; -.
DR   SMR; Q5EB14; -.
DR   STRING; 7955.ENSDARP00000025588; -.
DR   PaxDb; Q5EB14; -.
DR   Ensembl; ENSDART00000006093; ENSDARP00000025588; ENSDARG00000015158.
DR   GeneID; 503533; -.
DR   KEGG; dre:503533; -.
DR   CTD; 55974; -.
DR   ZFIN; ZDB-GENE-050220-11; slc50a1.
DR   eggNOG; KOG1623; Eukaryota.
DR   GeneTree; ENSGT00390000007801; -.
DR   HOGENOM; CLU_048643_3_0_1; -.
DR   InParanoid; Q5EB14; -.
DR   OMA; QLNDYYI; -.
DR   OrthoDB; 1116261at2759; -.
DR   PhylomeDB; Q5EB14; -.
DR   TreeFam; TF313635; -.
DR   Reactome; R-DRE-189200; Cellular hexose transport.
DR   PRO; PR:Q5EB14; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000015158; Expressed in mature ovarian follicle and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..219
FT                   /note="Sugar transporter SWEET1"
FT                   /id="PRO_0000345119"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          5..90
FT                   /note="MtN3/slv 1"
FT   DOMAIN          124..204
FT                   /note="MtN3/slv 2"
SQ   SEQUENCE   219 AA;  24803 MW;  FBFE2686A5A8095F CRC64;
     MDFLQLLSCA CIIFTVGMFT TGLTDLKKMK ATQSADNVQF LPFLTTCLNN LGWLYYGLLK
     GDGTVIFVNI IGAFLQTVYI ATYCHYTKEK RRVYTQTLLM VSVLCVAWVY FSLVISPGEA
     QLSQLGLTCS VFTISMYLSP LADLLDIMRT KSVERLSFSL TVATFFTSTS WTLYGLQLGD
     YYIMVPNTPG IFTSLIRFFL FWWFGAVIPQ IPSYKLIQI