SWET1_DICDI
ID SWET1_DICDI Reviewed; 220 AA.
AC Q54JW5;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Sugar transporter SWEET1;
GN Name=slc50a1; ORFNames=DDB_G0287763;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000104; EAL63528.1; -; Genomic_DNA.
DR RefSeq; XP_637037.1; XM_631945.1.
DR AlphaFoldDB; Q54JW5; -.
DR SMR; Q54JW5; -.
DR TCDB; 2.A.123.1.14; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR PaxDb; Q54JW5; -.
DR EnsemblProtists; EAL63528; EAL63528; DDB_G0287763.
DR GeneID; 8626291; -.
DR KEGG; ddi:DDB_G0287763; -.
DR dictyBase; DDB_G0287763; -.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_1_0_1; -.
DR InParanoid; Q54JW5; -.
DR OMA; VMLFCNA; -.
DR PhylomeDB; Q54JW5; -.
DR Reactome; R-DDI-189200; Cellular hexose transport.
DR PRO; PR:Q54JW5; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..220
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345126"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 12..92
FT /note="MtN3/slv 1"
FT DOMAIN 134..217
FT /note="MtN3/slv 2"
SQ SEQUENCE 220 AA; 25012 MW; 9E42189A51340A4D CRC64;
MEDEKNENLM TFIQFCATFI TITLFIMPLK TIRLIIEKKN VGTVAGLQFI SSVLNCFLWI
SYALLTSNTT MLFVNSIGMM FSIYYVFNYW KNINQVRASR DYLKKVMIAC VLAITIISIS
YYNTVDDLDT RISRLGFLSS VVCVLMFASP LEKMAIVIQS KNSEGMIINV AILSLLCGLS
WTIFGLLLND IYIYLPNILA SILSFVQLTL IKLYPPQILL
