SWET1_DROME
ID SWET1_DROME Reviewed; 226 AA.
AC Q7JVE7; O96879;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Sugar transporter SWEET1;
DE AltName: Full=Protein saliva;
GN Name=slv; ORFNames=CG8717;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=9739134; DOI=10.1016/s0925-4773(98)00087-2;
RA Artero R.D., Terol-Alcayde J., Paricio N., Ring J., Bargues M., Torres A.,
RA Perez-Alonso M.;
RT "saliva, a new Drosophila gene expressed in the embryonic salivary glands
RT with homologues in plants and vertebrates.";
RL Mech. Dev. 75:159-162(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout development with the highest
CC expression in embryos from 4 to 12 h. Expressed in the salivary glands
CC from stage 11, when the placodes are being specified.
CC {ECO:0000269|PubMed:9739134}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD03390.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U70979; AAD03390.1; ALT_FRAME; mRNA.
DR EMBL; AE013599; AAF59142.1; -; Genomic_DNA.
DR EMBL; AY118993; AAM50853.1; -; mRNA.
DR RefSeq; NP_001260797.1; NM_001273868.2.
DR RefSeq; NP_001286182.1; NM_001299253.1.
DR RefSeq; NP_477383.1; NM_058035.4.
DR AlphaFoldDB; Q7JVE7; -.
DR SMR; Q7JVE7; -.
DR BioGRID; 61632; 2.
DR IntAct; Q7JVE7; 1.
DR STRING; 7227.FBpp0302050; -.
DR TCDB; 2.A.123.1.12; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR PaxDb; Q7JVE7; -.
DR DNASU; 35773; -.
DR EnsemblMetazoa; FBtr0088824; FBpp0087900; FBgn0025469.
DR EnsemblMetazoa; FBtr0310369; FBpp0302050; FBgn0025469.
DR EnsemblMetazoa; FBtr0339280; FBpp0308389; FBgn0025469.
DR GeneID; 35773; -.
DR KEGG; dme:Dmel_CG8717; -.
DR UCSC; CG8717-RA; d. melanogaster.
DR CTD; 35773; -.
DR FlyBase; FBgn0025469; slv.
DR VEuPathDB; VectorBase:FBgn0025469; -.
DR eggNOG; KOG1623; Eukaryota.
DR GeneTree; ENSGT00390000007801; -.
DR HOGENOM; CLU_048643_3_3_1; -.
DR InParanoid; Q7JVE7; -.
DR OMA; VMSINIF; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q7JVE7; -.
DR BioGRID-ORCS; 35773; 0 hits in 1 CRISPR screen.
DR ChiTaRS; svr; fly.
DR GenomeRNAi; 35773; -.
DR PRO; PR:Q7JVE7; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0025469; Expressed in salivary gland body primordium (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q7JVE7; baseline and differential.
DR Genevisible; Q7JVE7; DM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0007431; P:salivary gland development; IEP:UniProtKB.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..226
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345122"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 9..93
FT /note="MtN3/slv 1"
FT DOMAIN 128..210
FT /note="MtN3/slv 2"
SQ SEQUENCE 226 AA; 25112 MW; 66666CA306642DBC CRC64;
MSAVAYDSLL STTAVISTVF QFLSGAMICR KYIQKKSTGD SSGVPFICGF LSCSFWLRYG
VLTNEQSIVL VNIIGSTLFL VYTLIYYVFT VNKRACVKQF GFVLTVLVVV IVYTNRLEDQ
RDRMIHVTGI VCCIVTVCFF AAPLASLLHV IRAKNSESLP LPLIATSFVV SLQWLIYGIL
ISDSFIQIPN FLGCILSLLQ LGLFVLYPPR SYSGHGYKLV EQAVPF
