ID   SWET1_DROPS             Reviewed;         226 AA.
AC   Q290X1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Sugar transporter SWEET1;
DE   AltName: Full=Protein saliva;
GN   Name=slv; ORFNames=GA21278;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC       the membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
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DR   EMBL; CM000071; EAL25241.1; -; Genomic_DNA.
DR   RefSeq; XP_001360666.1; XM_001360629.3.
DR   AlphaFoldDB; Q290X1; -.
DR   SMR; Q290X1; -.
DR   STRING; 7237.FBpp0276749; -.
DR   EnsemblMetazoa; FBtr0278311; FBpp0276749; FBgn0081266.
DR   GeneID; 4804038; -.
DR   KEGG; dpo:Dpse_GA21278; -.
DR   eggNOG; KOG1623; Eukaryota.
DR   HOGENOM; CLU_048643_3_3_1; -.
DR   InParanoid; Q290X1; -.
DR   OMA; VMSINIF; -.
DR   PhylomeDB; Q290X1; -.
DR   ChiTaRS; svr; fly.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0081266; Expressed in male reproductive system and 2 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0007431; P:salivary gland development; ISS:UniProtKB.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..226
FT                   /note="Sugar transporter SWEET1"
FT                   /id="PRO_0000345123"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          8..92
FT                   /note="MtN3/slv 1"
FT   DOMAIN          129..210
FT                   /note="MtN3/slv 2"
SQ   SEQUENCE   226 AA;  25244 MW;  8E1FDB84E95AA4D0 CRC64;
     MSAVAYELLS TTAVISTVFQ FLSGAMICRK YIQKKSTGDS SGVPFICGFL SCSFWLRYGV
     LTEEQSIVLV NIIGSTLFLI YTLIYYVFTV NKRAFVRQFA FVLAVLIAVV VVYTNRLADQ
     RDEMIRITGI FCCIVTVCFF AAPLATLLHV IRAKNSESLP LPLIATSFLV SLQWLIYGIL
     ISDSFIQIPN FLGCLLSMLQ LSLFVVYPPR SYSGQGYKLV EQAVPF