SWET1_HUMAN
ID SWET1_HUMAN Reviewed; 221 AA.
AC Q9BRV3; Q5SR64; Q6IAK6; Q96DC5; Q9UHQ2; Q9UHQ3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Sugar transporter SWEET1;
DE Short=HsSWEET1;
DE AltName: Full=RAG1-activating protein 1;
DE AltName: Full=Solute carrier family 50 member 1;
DE AltName: Full=Stromal cell protein;
GN Name=SLC50A1; Synonyms=RAG1AP1, SCP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
CC -!- FUNCTION: Mediates sugar transport across membranes. May stimulate
CC V(D)J recombination by the activation of RAG1.
CC {ECO:0000269|PubMed:21107422}.
CC -!- SUBUNIT: Interacts with TRPV2; the interaction probably occurs
CC intracellularly and depends on TRPV2 N-glycosylation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BRV3; Q96E29: MTERF3; NbExp=3; IntAct=EBI-8634123, EBI-7825321;
CC Q9BRV3; O00560: SDCBP; NbExp=3; IntAct=EBI-8634123, EBI-727004;
CC Q9BRV3; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-8634123, EBI-2872322;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:21107422}. Cell membrane
CC {ECO:0000269|PubMed:21107422}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:21107422}. Note=May also localize to the
CC endoplasmic reticulum. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9BRV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRV3-2; Sequence=VSP_034916, VSP_034917;
CC Name=3;
CC IsoId=Q9BRV3-3; Sequence=VSP_034918;
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in
CC oviduct, epididymis and intestine. {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION: [Isoform 2]:
CC Sequence=AAF17233.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF126023; AAF17232.1; -; mRNA.
DR EMBL; AF126024; AAF17233.1; ALT_FRAME; mRNA.
DR EMBL; AK289551; BAF82240.1; -; mRNA.
DR EMBL; CR457148; CAG33429.1; -; mRNA.
DR EMBL; AL691442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC005943; AAH05943.1; -; mRNA.
DR EMBL; BC009621; AAH09621.1; -; mRNA.
DR CCDS; CCDS1093.1; -. [Q9BRV3-1]
DR CCDS; CCDS44238.1; -. [Q9BRV3-3]
DR CCDS; CCDS44239.1; -. [Q9BRV3-2]
DR RefSeq; NP_001116309.1; NM_001122837.1. [Q9BRV3-2]
DR RefSeq; NP_001116311.1; NM_001122839.1. [Q9BRV3-3]
DR RefSeq; NP_001274515.1; NM_001287586.1.
DR RefSeq; NP_001274516.1; NM_001287587.1.
DR RefSeq; NP_001274517.1; NM_001287588.1.
DR RefSeq; NP_001274519.1; NM_001287590.1.
DR RefSeq; NP_001274520.1; NM_001287591.1.
DR RefSeq; NP_001274521.1; NM_001287592.1.
DR RefSeq; NP_061333.2; NM_018845.3. [Q9BRV3-1]
DR AlphaFoldDB; Q9BRV3; -.
DR SMR; Q9BRV3; -.
DR BioGRID; 121020; 5.
DR IntAct; Q9BRV3; 5.
DR MINT; Q9BRV3; -.
DR STRING; 9606.ENSP00000357389; -.
DR TCDB; 2.A.123.1.4; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR iPTMnet; Q9BRV3; -.
DR PhosphoSitePlus; Q9BRV3; -.
DR BioMuta; SLC50A1; -.
DR DMDM; 74752289; -.
DR MassIVE; Q9BRV3; -.
DR PaxDb; Q9BRV3; -.
DR PeptideAtlas; Q9BRV3; -.
DR PRIDE; Q9BRV3; -.
DR ProteomicsDB; 78840; -. [Q9BRV3-1]
DR ProteomicsDB; 78841; -. [Q9BRV3-2]
DR ProteomicsDB; 78842; -. [Q9BRV3-3]
DR Antibodypedia; 3097; 71 antibodies from 19 providers.
DR DNASU; 55974; -.
DR Ensembl; ENST00000303343.12; ENSP00000306146.8; ENSG00000169241.19. [Q9BRV3-3]
DR Ensembl; ENST00000368401.6; ENSP00000357386.5; ENSG00000169241.19. [Q9BRV3-2]
DR Ensembl; ENST00000368404.9; ENSP00000357389.4; ENSG00000169241.19. [Q9BRV3-1]
DR GeneID; 55974; -.
DR KEGG; hsa:55974; -.
DR MANE-Select; ENST00000368404.9; ENSP00000357389.4; NM_018845.4; NP_061333.2.
DR UCSC; uc001fhj.5; human. [Q9BRV3-1]
DR CTD; 55974; -.
DR DisGeNET; 55974; -.
DR GeneCards; SLC50A1; -.
DR HGNC; HGNC:30657; SLC50A1.
DR HPA; ENSG00000169241; Low tissue specificity.
DR MIM; 613683; gene.
DR neXtProt; NX_Q9BRV3; -.
DR OpenTargets; ENSG00000169241; -.
DR PharmGKB; PA142671099; -.
DR VEuPathDB; HostDB:ENSG00000169241; -.
DR eggNOG; KOG1623; Eukaryota.
DR GeneTree; ENSGT00390000007801; -.
DR HOGENOM; CLU_048643_3_0_1; -.
DR InParanoid; Q9BRV3; -.
DR OMA; QLNDYYI; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9BRV3; -.
DR TreeFam; TF313635; -.
DR PathwayCommons; Q9BRV3; -.
DR Reactome; R-HSA-189200; Cellular hexose transport.
DR SignaLink; Q9BRV3; -.
DR BioGRID-ORCS; 55974; 12 hits in 1080 CRISPR screens.
DR ChiTaRS; SLC50A1; human.
DR GenomeRNAi; 55974; -.
DR Pharos; Q9BRV3; Tbio.
DR PRO; PR:Q9BRV3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BRV3; protein.
DR Bgee; ENSG00000169241; Expressed in mucosa of transverse colon and 192 other tissues.
DR ExpressionAtlas; Q9BRV3; baseline and differential.
DR Genevisible; Q9BRV3; HS.
DR GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0042947; F:glucoside transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Golgi apparatus; Membrane;
KW Reference proteome; Repeat; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..221
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345116"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 10..94
FT /note="MtN3/slv 1"
FT DOMAIN 127..212
FT /note="MtN3/slv 2"
FT REGION 149..221
FT /note="Mediates interaction with TRPV2"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10931946"
FT /id="VSP_034916"
FT VAR_SEQ 56..94
FT /note="GWLSYGALKGDGILIVVNTVGAALQTLYILAYLHYCPRK -> MRGLHPWHV
FT LRRPLGPQAHANDPECGQRPVPALSHHGSQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10931946"
FT /id="VSP_034917"
FT VAR_SEQ 95..148
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034918"
FT CONFLICT 43
FT /note="Q -> R (in Ref. 1; AAF17232)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="G -> A (in Ref. 3; CAG33429)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 221 AA; 25030 MW; FEC35396C28EA9F0 CRC64;
MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY
GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ TATLLGVLLL GYGYFWLLVP
NPEARLQQLG LFCSVFTISM YLSPLADLAK VIQTKSTQCL SYPLTIATLL TSASWCLYGF
RLRDPYIMVS NFPGIVTSFI RFWLFWKYPQ EQDRNYWLLQ T
