SWET1_MOUSE
ID SWET1_MOUSE Reviewed; 221 AA.
AC Q9CXK4; Q62275;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Sugar transporter SWEET1;
DE Short=MmSWEET1;
DE AltName: Full=RAG1-activating protein 1;
DE AltName: Full=Solute carrier family 50 member 1;
GN Name=Slc50a1; Synonyms=Rag1ap1, Rga;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=8630032; DOI=10.1006/bbrc.1996.0667;
RA Tagoh H., Kishi H., Muraguchi A.;
RT "Molecular cloning and characterization of a novel stromal cell-derived
RT cDNA encoding a protein that facilitates gene activation of recombination
RT activating gene (RAG)-1 in human lymphoid progenitors.";
RL Biochem. Biophys. Res. Commun. 221:744-749(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INDUCTION.
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
CC -!- FUNCTION: Mediates sugar transport across membranes (By similarity).
CC May regulate the expression of RAG1 a gene involved in V(D)J
CC recombination. {ECO:0000250, ECO:0000269|PubMed:8630032}.
CC -!- SUBUNIT: Interacts with TRPV2; the interaction probably occurs
CC intracellularly and depends on TRPV2 N-glycosylation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Note=May also localize to
CC the endoplasmic reticulum. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in lung, placenta, spleen
CC and thymus, at intermediate levels in brain, heart, kidney and testis,
CC and at low levels in bone marrow, liver and lymph node. Within the
CC thymus expression is highest in non-lymphoid cells.
CC {ECO:0000269|PubMed:8630032}.
CC -!- INDUCTION: Up-regulated in mammary gland during lactation.
CC {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; X96618; CAA65438.1; -; mRNA.
DR EMBL; AK014305; BAB29259.1; -; mRNA.
DR EMBL; AK170162; BAE41608.1; -; mRNA.
DR EMBL; BC014292; AAH14292.1; -; mRNA.
DR CCDS; CCDS17500.1; -.
DR PIR; JC4761; JC4761.
DR RefSeq; NP_033083.2; NM_009057.3.
DR AlphaFoldDB; Q9CXK4; -.
DR SMR; Q9CXK4; -.
DR STRING; 10090.ENSMUSP00000029565; -.
DR TCDB; 2.A.123.1.8; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR PhosphoSitePlus; Q9CXK4; -.
DR SwissPalm; Q9CXK4; -.
DR PaxDb; Q9CXK4; -.
DR PRIDE; Q9CXK4; -.
DR ProteomicsDB; 254787; -.
DR Antibodypedia; 3097; 71 antibodies from 19 providers.
DR DNASU; 19729; -.
DR Ensembl; ENSMUST00000029565; ENSMUSP00000029565; ENSMUSG00000027953.
DR GeneID; 19729; -.
DR KEGG; mmu:19729; -.
DR UCSC; uc008pyn.2; mouse.
DR CTD; 55974; -.
DR MGI; MGI:107417; Slc50a1.
DR VEuPathDB; HostDB:ENSMUSG00000027953; -.
DR eggNOG; KOG1623; Eukaryota.
DR GeneTree; ENSGT00390000007801; -.
DR InParanoid; Q9CXK4; -.
DR OMA; QLNDYYI; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9CXK4; -.
DR TreeFam; TF313635; -.
DR Reactome; R-MMU-189200; Cellular hexose transport.
DR BioGRID-ORCS; 19729; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Slc50a1; mouse.
DR PRO; PR:Q9CXK4; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CXK4; protein.
DR Bgee; ENSMUSG00000027953; Expressed in peripheral lymph node and 238 other tissues.
DR ExpressionAtlas; Q9CXK4; baseline and differential.
DR Genevisible; Q9CXK4; MM.
DR GO; GO:0012505; C:endomembrane system; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042947; F:glucoside transmembrane transporter activity; ISO:MGI.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..221
FT /note="Sugar transporter SWEET1"
FT /id="PRO_0000345117"
FT TRANSMEM 3..23
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT DOMAIN 10..94
FT /note="MtN3/slv 1"
FT DOMAIN 127..212
FT /note="MtN3/slv 2"
FT REGION 149..221
FT /note="Mediates interaction with TRPV2"
FT /evidence="ECO:0000250"
FT CONFLICT 188
FT /note="T -> A (in Ref. 1; CAA65438)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 221 AA; 24649 MW; 60FA342447ABA45C CRC64;
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT DVNNLSWLSY
GVLKGDGTLI IVNSVGAVLQ TLYILAYLHY SPQKHGVLLQ TATLLAVLLL GYGYFWLLVP
DLEARLQQLG LFCSVFTISM YLSPLADLAK IVQTKSTQRL SFSLTIATLF CSASWSIYGF
RLRDPYITVP NLPGILTSLI RLGLFCKYPP EQDRKYRLLQ T
