ID   SWET1_PAPAN             Reviewed;         221 AA.
AC   Q95KW8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Sugar transporter SWEET1;
DE   AltName: Full=Solute carrier family 50 member 1;
DE   AltName: Full=Uterine stromal cell protein;
GN   Name=SLC50A1;
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lobo S., Brudney A., Barkai U., Johnson C., Lessey B., Fazleabas A.;
RT   "Stromal cell protein expression in the baboon uterus.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates sugar transport across membranes. May stimulate
CC       V(D)J recombination by the activation of RAG1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TRPV2; the interaction probably occurs
CC       intracellularly and depends on TRPV2 N-glycosylation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=May also localize to
CC       the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
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DR   EMBL; AY057106; AAL11334.1; -; mRNA.
DR   RefSeq; NP_001106098.1; NM_001112628.1.
DR   AlphaFoldDB; Q95KW8; -.
DR   SMR; Q95KW8; -.
DR   STRING; 9555.ENSPANP00000002936; -.
DR   GeneID; 100126708; -.
DR   KEGG; panu:100126708; -.
DR   CTD; 55974; -.
DR   eggNOG; KOG1623; Eukaryota.
DR   OrthoDB; 1116261at2759; -.
DR   Proteomes; UP000028761; Unplaced.
DR   GO; GO:0012505; C:endomembrane system; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..221
FT                   /note="Sugar transporter SWEET1"
FT                   /id="PRO_0000345118"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          10..94
FT                   /note="MtN3/slv 1"
FT   DOMAIN          127..212
FT                   /note="MtN3/slv 2"
FT   REGION          149..221
FT                   /note="Mediates interaction with TRPV2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  25119 MW;  4D7B61F1497C1D0E CRC64;
     MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT EVNNLGWLSY
     GALKGDRILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ TATLLGVLLL GYGYFWLLVP
     NPEARLQLLG LFCSVFTISM YLSPLADLAK VIQTKSTQCL SYPLTIATVL TSASWCLYGF
     RLRVPYIMVS NFPGIVTSFI RFWLFWKYPQ EQDRNYWFLQ T