ID   SWET1_XENLA             Reviewed;         216 AA.
AC   Q6NTJ7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Sugar transporter SWEET1;
DE   AltName: Full=Solute carrier family 50 member 1;
GN   Name=slc50a1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates sugar transport across membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
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DR   EMBL; BC068964; AAH68964.1; -; mRNA.
DR   RefSeq; NP_001084504.1; NM_001091035.1.
DR   AlphaFoldDB; Q6NTJ7; -.
DR   SMR; Q6NTJ7; -.
DR   DNASU; 414448; -.
DR   GeneID; 414448; -.
DR   KEGG; xla:414448; -.
DR   CTD; 414448; -.
DR   Xenbase; XB-GENE-6252851; slc50a1.L.
DR   OrthoDB; 1116261at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 414448; Expressed in liver and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Golgi apparatus; Membrane; Reference proteome; Repeat;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..216
FT                   /note="Sugar transporter SWEET1"
FT                   /id="PRO_0000345120"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          6..90
FT                   /note="MtN3/slv 1"
FT   DOMAIN          124..206
FT                   /note="MtN3/slv 2"
SQ   SEQUENCE   216 AA;  24372 MW;  2E39C203FDB13501 CRC64;
     MDWMWLLSGA CIVFTLGMFS SGLSDLRVMV AQRSVENIQY LPFLTTDLNN LGWFYYGYLK
     GDGTLMIVNV IGASLQSLYM GAYLLYSPER RYVGSQVLVS LGVLLLGYCY FTLWILDLNS
     RLNQLGLFCS VFTISMYLSP LADLAQIIRS KSTKCLSFPL TVATFLTSSS WVLYGLVQSD
     LYITVPNFPG IVTSLVRFWL FSQFPPDPPT YRLLQA