SWET2_ARATH
ID SWET2_ARATH Reviewed; 236 AA.
AC Q9LH79; Q0WLP7;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Bidirectional sugar transporter SWEET2 {ECO:0000303|PubMed:21107422};
DE Short=AtSWEET2 {ECO:0000303|PubMed:21107422};
DE AltName: Full=Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 2 {ECO:0000303|PubMed:21107422};
GN Name=SWEET2 {ECO:0000303|PubMed:21107422}; OrderedLocusNames=At3g14770;
GN ORFNames=T21E2.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-236.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION BY PATHOGENS, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [6]
RP INTERACTION WITH SWEET17.
RX PubMed=24027245; DOI=10.1073/pnas.1311244110;
RA Xuan Y.H., Hu Y.B., Chen L.-Q., Sosso D., Ducat D.C., Hou B.-H.,
RA Frommer W.B.;
RT "Functional role of oligomerization for bacterial and plant SWEET sugar
RT transporter family.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E3685-E3685(2013).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane. {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SUBUNIT: Forms heterooligomers with SWEET17.
CC {ECO:0000269|PubMed:24027245}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- INDUCTION: Slightly induced by the powdery mildew fungus
CC G.cichoracearum and the pathogenic bacteria P.syringae pv. tomato.
CC {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AP002061; BAB02642.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75565.1; -; Genomic_DNA.
DR EMBL; AY054229; AAL06889.1; -; mRNA.
DR EMBL; AY066044; AAL47411.1; -; mRNA.
DR EMBL; AK230146; BAF01960.1; -; mRNA.
DR RefSeq; NP_566493.1; NM_112338.5.
DR AlphaFoldDB; Q9LH79; -.
DR SMR; Q9LH79; -.
DR BioGRID; 6039; 3.
DR IntAct; Q9LH79; 2.
DR STRING; 3702.AT3G14770.1; -.
DR PaxDb; Q9LH79; -.
DR PRIDE; Q9LH79; -.
DR ProteomicsDB; 226532; -.
DR EnsemblPlants; AT3G14770.1; AT3G14770.1; AT3G14770.
DR GeneID; 820705; -.
DR Gramene; AT3G14770.1; AT3G14770.1; AT3G14770.
DR KEGG; ath:AT3G14770; -.
DR Araport; AT3G14770; -.
DR TAIR; locus:2099362; AT3G14770.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_1_1_1; -.
DR OMA; QLNDYYI; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9LH79; -.
DR PRO; PR:Q9LH79; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LH79; baseline and differential.
DR Genevisible; Q9LH79; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..236
FT /note="Bidirectional sugar transporter SWEET2"
FT /id="PRO_0000404103"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..103
FT /note="MtN3/slv 1"
FT DOMAIN 138..221
FT /note="MtN3/slv 2"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 236 AA; 26467 MW; E82A4A4C4EC3DD78 CRC64;
MDVFAFNASL SMCKDVAGIA GNIFAFGLFV SPMPTFRRIM RNKSTEQFSG LPYIYALLNC
LICLWYGTPF ISHSNAMLMT VNSVGATFQL CYIILFIMHT DKKNKMKMLG LLFVVFAVVG
VIVAGSLQIP DQLTRWYFVG FLSCGSLVSM FASPLFVINL VIRTKSVEFM PFYLSLSTFL
MSASFLLYGL FNSDAFVYTP NGIGTILGIV QLALYCYYHR NSIEEETKEP LIVSYV
