SWET4_ARATH
ID SWET4_ARATH Reviewed; 251 AA.
AC Q944M5; Q8GXD7; Q8LD36; Q9LRT5;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Bidirectional sugar transporter SWEET4 {ECO:0000303|PubMed:21107422};
DE Short=AtSWEET4 {ECO:0000303|PubMed:21107422};
DE AltName: Full=Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 4 {ECO:0000303|PubMed:21107422};
GN Name=SWEET4 {ECO:0000303|PubMed:21107422}; OrderedLocusNames=At3g28007;
GN ORFNames=MMG15.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 148-251.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP INDUCTION BY PATHOGENS, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [7]
RP SUBUNIT, INTERACTION WITH SWEET8 AND SWEET17, AND SUBCELLULAR LOCATION.
RX PubMed=24027245; DOI=10.1073/pnas.1311244110;
RA Xuan Y.H., Hu Y.B., Chen L.-Q., Sosso D., Ducat D.C., Hou B.-H.,
RA Frommer W.B.;
RT "Functional role of oligomerization for bacterial and plant SWEET sugar
RT transporter family.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E3685-E3685(2013).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane. {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SUBUNIT: Forms homooligomers and heterooligomers with SWEET8 and
CC SWEET17. {ECO:0000269|PubMed:24027245}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24027245};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- INDUCTION: Induced by the pathogenic bacteria P.syringae pv. tomato,
CC and slightly induced by the powdery mildew fungus G.cichoracearum and
CC the fungal pathogen B.cinerea. {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC42911.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB028616; BAB01122.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77391.1; -; Genomic_DNA.
DR EMBL; AF428275; AAL16107.1; -; mRNA.
DR EMBL; BT002215; AAN72227.1; -; mRNA.
DR EMBL; AY086230; AAM64306.1; -; mRNA.
DR EMBL; AK118293; BAC42911.1; ALT_INIT; mRNA.
DR RefSeq; NP_566829.1; NM_113718.5.
DR AlphaFoldDB; Q944M5; -.
DR SMR; Q944M5; -.
DR BioGRID; 7754; 2.
DR STRING; 3702.AT3G28007.1; -.
DR PaxDb; Q944M5; -.
DR PRIDE; Q944M5; -.
DR ProteomicsDB; 226553; -.
DR EnsemblPlants; AT3G28007.1; AT3G28007.1; AT3G28007.
DR GeneID; 822424; -.
DR Gramene; AT3G28007.1; AT3G28007.1; AT3G28007.
DR KEGG; ath:AT3G28007; -.
DR Araport; AT3G28007; -.
DR TAIR; locus:505006381; AT3G28007.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_1_0_1; -.
DR InParanoid; Q944M5; -.
DR OMA; LWLIGEM; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q944M5; -.
DR PRO; PR:Q944M5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q944M5; baseline and differential.
DR Genevisible; Q944M5; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..251
FT /note="Bidirectional sugar transporter SWEET4"
FT /id="PRO_0000404105"
FT TOPO_DOM 1..12
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..72
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..186
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..213
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 12..96
FT /note="MtN3/slv 1"
FT DOMAIN 133..216
FT /note="MtN3/slv 2"
FT REGION 220..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 84
FT /note="L -> V (in Ref. 4; AAM64306)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="K -> N (in Ref. 4; AAM64306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 251 AA; 27815 MW; C474BF8A9571238B CRC64;
MVNATVARNI AGICGNVISL FLFLSPIPTF ITIYKKKKVE EYKADPYLAT VLNCALWVFY
GLPMVQPDSL LVITINGTGL AIELVYLAIF FFFSPTSRKV KVGLWLIGEM VFVGIVATCT
LLLFHTHNQR SSFVGIFCVI FVSLMYIAPL TIMSKVIKTK SVKYMPFSLS LANFLNGVVW
VIYALIKFDL FILIGNGLGT VSGAVQLILY ACYYKTTPKD DEDEEDEENL SKVNSQLQLS
GNSGQAKRVS A
