ID   ABITM_PONAB             Reviewed;         181 AA.
AC   Q5RFS0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Protein Abitram {ECO:0000305};
DE   AltName: Full=Actin-binding transcription modulator;
DE   AltName: Full=Protein Simiate;
GN   Name=ABITRAM; Synonyms=FAM206A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actin-binding protein that regulates actin polymerization,
CC       filopodia dynamics and increases the branching of proximal dendrites of
CC       developing neurons. {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SUBUNIT: Interacts with F-actin (By similarity). Interacts with G-actin
CC       (By similarity). {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q80ZQ9}.
CC       Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q80ZQ9}. Nucleus
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, growth cone
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q80ZQ9}. Note=Localizes to somata and dendrites
CC       in cortical neurons (By similarity). Colocalizes with F- and G-actin in
CC       lamellipodia (By similarity). Colocalizes in the nucleus with PTK2 (By
CC       similarity). {ECO:0000250|UniProtKB:Q80ZQ9}.
CC   -!- MISCELLANEOUS: The name derives from simia, latin, a female ape, and M,
CC       A, T and E, the first four amino acids of the ape orthologs.
CC   -!- SIMILARITY: Belongs to the ABITRAM family. {ECO:0000305}.
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DR   EMBL; CR857082; CAH89387.1; -; mRNA.
DR   RefSeq; NP_001127141.1; NM_001133669.1.
DR   RefSeq; XP_009243001.1; XM_009244726.1.
DR   AlphaFoldDB; Q5RFS0; -.
DR   SMR; Q5RFS0; -.
DR   STRING; 9601.ENSPPYP00000021823; -.
DR   Ensembl; ENSPPYT00000022719; ENSPPYP00000021823; ENSPPYG00000019483.
DR   GeneID; 100174191; -.
DR   KEGG; pon:100174191; -.
DR   CTD; 54942; -.
DR   eggNOG; KOG3266; Eukaryota.
DR   GeneTree; ENSGT00450000040303; -.
DR   HOGENOM; CLU_107323_1_0_1; -.
DR   InParanoid; Q5RFS0; -.
DR   OMA; GRPCEDF; -.
DR   OrthoDB; 1277002at2759; -.
DR   TreeFam; TF313930; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0032433; C:filopodium tip; ISS:UniProtKB.
DR   GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR   GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR   GO; GO:0003785; F:actin monomer binding; ISS:UniProtKB.
DR   GO; GO:0048813; P:dendrite morphogenesis; ISS:UniProtKB.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
DR   GO; GO:0051489; P:regulation of filopodium assembly; ISS:UniProtKB.
DR   InterPro; IPR039169; Abitram.
DR   InterPro; IPR033753; GCV_H/Fam206.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR13651; PTHR13651; 1.
DR   Pfam; PF01597; GCV_H; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell projection; Nucleus; Reference proteome.
FT   CHAIN           1..181
FT                   /note="Protein Abitram"
FT                   /id="PRO_0000291930"
SQ   SEQUENCE   181 AA;  20378 MW;  2336750B1E59EB32 CRC64;
     MATEPEAAEP VVPSLVDRYF TRWYKPDVKG KFCEDHCILQ HSNRICVITL AESHPVLQSG
     KTIKSISYQI STNCSRLQNK VSGKFKRGAQ FLTELAPLCK IYCSDGEEYT VSSCVRGRLM
     EVNENILHKP SILQEKPSTE GYIAVVLPKF EESKSITEGL LTQKQYEEVM VKRINATTAT
     S