SWET5_ORYSJ
ID SWET5_ORYSJ Reviewed; 237 AA.
AC Q6L568; A0A0P0WQZ4;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Bidirectional sugar transporter SWEET5;
DE Short=OsSWEET5;
GN Name=SWEET5; OrderedLocusNames=Os05g0588500, LOC_Os05g51090;
GN ORFNames=OJ1007_H05.17, OJ1115_D04.3, OsJ_19730;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [8]
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Zhonghua 11;
RX PubMed=24709840; DOI=10.1371/journal.pone.0094210;
RA Zhou Y., Liu L., Huang W., Yuan M., Zhou F., Li X., Lin Y.;
RT "Overexpression of OsSWEET5 in rice causes growth retardation and
RT precocious senescence.";
RL PLoS ONE 9:E94210-E94210(2014).
RN [9]
RP REVIEW.
RX PubMed=25988582; DOI=10.1016/j.pbi.2015.04.005;
RA Eom J.-S., Chen L.-Q., Sosso D., Julius B.T., Lin I.W., Qu X.-Q.,
RA Braun D.M., Frommer W.B.;
RT "SWEETs, transporters for intracellular and intercellular sugar
RT translocation.";
RL Curr. Opin. Plant Biol. 25:53-62(2015).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane (By similarity). Can transport galactose. Prevents
CC growth but promotes senescence (PubMed:25988582, PubMed:24709840).
CC Involved in regulating the crosstalk between sugar and auxin. Regulates
CC negatively the auxin signaling pathway and translocation
CC (PubMed:24709840). {ECO:0000250|UniProtKB:Q8L9J7,
CC ECO:0000269|PubMed:24709840, ECO:0000303|PubMed:25988582}.
CC -!- SUBUNIT: Forms homooligomers and/or heterooligomers.
CC {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24709840};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in the floral organs at the
CC heading stage, and also in stem, root, senescing leaves, stamen, pistil
CC and hull. {ECO:0000269|PubMed:24709840}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AC098598; AAT44168.1; -; Genomic_DNA.
DR EMBL; AC105260; AAT37996.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF18389.1; -; Genomic_DNA.
DR EMBL; AP014961; BAS95600.1; -; Genomic_DNA.
DR EMBL; CM000142; EEE64873.1; -; Genomic_DNA.
DR EMBL; AK069614; BAG91518.1; -; mRNA.
DR RefSeq; XP_015638818.1; XM_015783332.1.
DR AlphaFoldDB; Q6L568; -.
DR SMR; Q6L568; -.
DR STRING; 4530.OS05T0588500-01; -.
DR PaxDb; Q6L568; -.
DR PRIDE; Q6L568; -.
DR EnsemblPlants; Os05t0588500-01; Os05t0588500-01; Os05g0588500.
DR GeneID; 4339772; -.
DR Gramene; Os05t0588500-01; Os05t0588500-01; Os05g0588500.
DR KEGG; osa:4339772; -.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_1_0_1; -.
DR InParanoid; Q6L568; -.
DR OMA; PKRCKML; -.
DR OrthoDB; 1116261at2759; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000007752; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q6L568; OS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0060918; P:auxin transport; IMP:UniProtKB.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0015757; P:galactose transmembrane transport; IDA:UniProtKB.
DR GO; GO:0010930; P:negative regulation of auxin mediated signaling pathway; IMP:UniProtKB.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 2: Evidence at transcript level;
KW Auxin signaling pathway; Cell membrane; Membrane; Reference proteome;
KW Repeat; Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..237
FT /note="Bidirectional sugar transporter SWEET5"
FT /id="PRO_0000404125"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 11..98
FT /note="MtN3/slv 1"
FT DOMAIN 134..216
FT /note="MtN3/slv 2"
SQ SEQUENCE 237 AA; 25917 MW; BC7B93C81313CB7E CRC64;
MVMNPDAVRN VVGIIGNLIS FGLFLSPLPT FVTIVKKKDV EEFVPDPYLA TFLNCALWVF
YGLPFIHPNS ILVVTINGTG LLIEIAYLAI YFAYAPKPKR CRMLGVLTVE LVFLAAVAAG
VLLGAHTYDK RSLIVGTLCV FFGTLMYAAP LTIMKQVIAT KSVEYMPFTL SLVSFINGIC
WTIYAFIRFD ILITIPNGMG TLLGAAQLIL YFCYYDGSTA KNKGALELPK DGDSSAV
