SWET6_ARATH
ID SWET6_ARATH Reviewed; 261 AA.
AC Q9C9M9;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Bidirectional sugar transporter SWEET6 {ECO:0000303|PubMed:21107422};
DE Short=AtSWEET6 {ECO:0000303|PubMed:21107422};
DE AltName: Full=Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 6 {ECO:0000303|PubMed:21107422};
GN Name=SWEET6 {ECO:0000303|PubMed:21107422}; OrderedLocusNames=At1g66770;
GN ORFNames=F4N21.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [4]
RP SUBUNIT, AND INTERACTION WITH SWEET5; SWEET8; SWEET11; SWEET13; SWEET15 AND
RP SWEET17.
RX PubMed=24027245; DOI=10.1073/pnas.1311244110;
RA Xuan Y.H., Hu Y.B., Chen L.-Q., Sosso D., Ducat D.C., Hou B.-H.,
RA Frommer W.B.;
RT "Functional role of oligomerization for bacterial and plant SWEET sugar
RT transporter family.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E3685-E3685(2013).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane. {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SUBUNIT: Forms homooligomers and heterooligomers with SWEET5, SWEET8,
CC SWEET11, SWEET13, SWEET15 and SWEET17. {ECO:0000269|PubMed:24027245}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AC013288; AAG60070.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34554.1; -; Genomic_DNA.
DR RefSeq; NP_176849.1; NM_105348.1.
DR AlphaFoldDB; Q9C9M9; -.
DR SMR; Q9C9M9; -.
DR BioGRID; 28216; 6.
DR STRING; 3702.AT1G66770.1; -.
DR PaxDb; Q9C9M9; -.
DR PRIDE; Q9C9M9; -.
DR EnsemblPlants; AT1G66770.1; AT1G66770.1; AT1G66770.
DR GeneID; 842995; -.
DR Gramene; AT1G66770.1; AT1G66770.1; AT1G66770.
DR KEGG; ath:AT1G66770; -.
DR Araport; AT1G66770; -.
DR TAIR; locus:2033319; AT1G66770.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_1_0_1; -.
DR InParanoid; Q9C9M9; -.
DR OMA; NAMMYAS; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9C9M9; -.
DR PRO; PR:Q9C9M9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9M9; baseline and differential.
DR Genevisible; Q9C9M9; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Repeat; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..261
FT /note="Bidirectional sugar transporter SWEET6"
FT /id="PRO_0000404107"
FT TOPO_DOM 1..11
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..74
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..134
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..168
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..261
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 12..99
FT /note="MtN3/slv 1"
FT DOMAIN 137..221
FT /note="MtN3/slv 2"
SQ SEQUENCE 261 AA; 28868 MW; 17DCDC0602EA24AF CRC64;
MVHEQLNLIR KIVGILGNFI SLCLFLSPTP TFIHIVKKKS VEKYSPLPYL ATLLNCLVRA
LYGLPMVHPD STLLVTISGI GITIEIVFLT IFFVFCGRQQ HRLVISAVLT VQVVFVATLA
VLVLTLEHTT DQRTISVGIV SCVFNAMMYA SPLSVMKMVI KTKSLEFMPF LLSVVGFLNA
GVWTIYGFVP FDPFLAIPNG IGCVFGLVQL ILYGTYYKST KGIMEERKNR LGYVGEVGLS
NAIAQTEPEN IPYLNKRVSG V
