SWI2_SCHPO
ID SWI2_SCHPO Reviewed; 722 AA.
AC Q10668;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Mating-type switching protein swi2;
GN Name=swi2; ORFNames=SPAC1142.03c, SPAC17G6.20c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RA Brandt U., Schmidt H.;
RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, AND INTERACTION WITH SWI5 AND RHP51.
RX PubMed=14663140; DOI=10.1073/pnas.2632890100;
RA Akamatsu Y., Dziadkowiec D., Ikeguchi M., Shinagawa H., Iwasaki H.;
RT "Two different Swi5-containing protein complexes are involved in mating-
RT type switching and recombination repair in fission yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:15770-15775(2003).
CC -!- FUNCTION: Required for normal mating-type switching.
CC {ECO:0000269|PubMed:14663140}.
CC -!- SUBUNIT: Interacts with swi5 and rhp51. {ECO:0000269|PubMed:14663140}.
CC -!- INTERACTION:
CC Q10668; P36601: rhp51; NbExp=3; IntAct=EBI-926914, EBI-926960;
CC Q10668; Q9UUB7: swi5; NbExp=5; IntAct=EBI-926914, EBI-926902;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X93590; CAA63788.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB77010.1; -; Genomic_DNA.
DR PIR; T46560; T46560.
DR RefSeq; NP_001018264.1; NM_001019690.2.
DR AlphaFoldDB; Q10668; -.
DR BioGRID; 280532; 22.
DR IntAct; Q10668; 3.
DR STRING; 4896.SPAC1142.03c.1; -.
DR SwissPalm; Q10668; -.
DR MaxQB; Q10668; -.
DR PaxDb; Q10668; -.
DR PRIDE; Q10668; -.
DR EnsemblFungi; SPAC1142.03c.1; SPAC1142.03c.1:pep; SPAC1142.03c.
DR GeneID; 3361456; -.
DR KEGG; spo:SPAC1142.03c; -.
DR PomBase; SPAC1142.03c; swi2.
DR VEuPathDB; FungiDB:SPAC1142.03c; -.
DR HOGENOM; CLU_383179_0_0_1; -.
DR OMA; FTTMLQE; -.
DR PRO; PR:Q10668; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0034974; C:Swi5-Swi2 complex; IPI:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IBA:GO_Central.
DR GO; GO:0007534; P:gene conversion at mating-type locus; IMP:PomBase.
PE 1: Evidence at protein level;
KW Cell cycle; Reference proteome.
FT CHAIN 1..722
FT /note="Mating-type switching protein swi2"
FT /id="PRO_0000072349"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 82177 MW; 5336DD1A81048946 CRC64;
MNVNKKQESI PVNTGSESIS SNDNERFEQG KGVGSNLGSH FFEPVEYYYS DGKPMNQTEA
SQMKGTFSRD FSLNEMNNEF ITDSFFCTTT PDPKTESPSF VKYNAHCDDH PEISGHVSSN
DKDFAYFEDK SENQPLVTLP NENNQVIEPL SSQSCKSQLS TQNYSESDFG WNQLCDLDPI
FKSLAFTDDT NLFPAFADSE AALIMLKKRE MTRVKHRAGR PRKYSYVNKD LNFEEGLPRR
RGRPTGWRKY PEKEEIYPTL SPRIKKPRKV FDAVVIPVTI KPSIYTEPSL PHHIDWNNGC
SEEFDFEPSR EDEDFPDLTS DSTGQDPLSS EPTIFDISPL PSDMEPTFSE NSLITINKMA
IEERKQSRRL EQPLAESQHQ EDLLNPYGVD QDFDETCINE SEQQATHIPN SSIKFNYDYT
PPKSATSHKH KRVDLLASRK ENVWTGLYGK VQTEMVSNRG EAVLNENNSK NRTNVTKPNS
YKNSVLSIGN NHSNHSNIIK PNTYKNTILS NENNTPNYSN VCLSTSLINR SLPSLKSTMH
PGVNKDLITR PFKNVNKMSV RKALIKPFHP PISKISRTRL TVSSPERLYC AKPISMATAP
SETDSKLINR IRNLELEIGG LKEQLSVVEL ALDTDKNSKQ IQVVERKIQN WRKSAQLAVE
VLFPVFSLKF TTMLQEVPQS VLRTSANDLR TKPCSIGTYL EQLQIPFHLL QYNSETESWD
LE
