SWI3A_ARATH
ID SWI3A_ARATH Reviewed; 512 AA.
AC Q8W475; Q8S8T3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=SWI/SNF complex subunit SWI3A;
DE Short=AtSWI3A;
DE AltName: Full=Transcription regulatory protein SWI3A;
GN Name=SWI3A; Synonyms=CHB1; OrderedLocusNames=At2g47620; ORFNames=T30B22.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=14682613; DOI=10.1023/b:plan.0000004305.60407.8b;
RA Zhou C., Miki B., Wu K.;
RT "CHB2, a member of the SWI3 gene family, is a global regulator in
RT Arabidopsis.";
RL Plant Mol. Biol. 52:1125-1134(2003).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH SWI3C; BSH AND FCA, AND
RP SUBUNIT.
RX PubMed=16055636; DOI=10.1105/tpc.105.031203;
RA Sarnowski T.J., Rios G., Jasik J., Swiezewski S., Kaczanowski S., Li Y.,
RA Kwiatkowska A., Pawlikowska K., Kozbial M., Kozbial P., Koncz C.,
RA Jerzmanowski A.;
RT "SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play
RT distinct roles during Arabidopsis development.";
RL Plant Cell 17:2454-2472(2005).
RN [6]
RP INTERACTION WITH BRM.
RX PubMed=16845477; DOI=10.1007/s11103-006-9021-2;
RA Hurtado L., Farrona S., Reyes J.C.;
RT "The putative SWI/SNF complex subunit BRAHMA activates flower homeotic
RT genes in Arabidopsis thaliana.";
RL Plant Mol. Biol. 62:291-304(2006).
CC -!- FUNCTION: Component of a multiprotein complex equivalent of the SWI/SNF
CC complex, an ATP-dependent chromatin-remodeling complex, which is
CC required for the positive and negative regulation of gene expression of
CC a large number of genes. It changes chromatin structure by altering
CC DNA-histone contacts within a nucleosome, leading eventually to a
CC change in nucleosome position, thus facilitating or repressing binding
CC of gene-specific transcription factors. {ECO:0000269|PubMed:16055636}.
CC -!- SUBUNIT: Homodimers and heterodimers. Interacts with SWI3B, SWI3C, BSH,
CC and the C-terminus of FCA, but not with BRM or SWI3D.
CC {ECO:0000269|PubMed:16055636, ECO:0000269|PubMed:16845477}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves and flowers, but
CC not in siliques. {ECO:0000269|PubMed:14682613}.
CC -!- DISRUPTION PHENOTYPE: Plants have an embryo development blocked at the
CC early globular stage. {ECO:0000269|PubMed:16055636}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM14849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002535; AAM14849.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10865.1; -; Genomic_DNA.
DR EMBL; AY062794; AAL32872.1; -; mRNA.
DR EMBL; AY081570; AAM10132.1; -; mRNA.
DR PIR; T00422; T00422.
DR RefSeq; NP_850476.1; NM_180145.3.
DR AlphaFoldDB; Q8W475; -.
DR SMR; Q8W475; -.
DR BioGRID; 4710; 78.
DR IntAct; Q8W475; 18.
DR STRING; 3702.AT2G47620.1; -.
DR PaxDb; Q8W475; -.
DR PRIDE; Q8W475; -.
DR ProteomicsDB; 226537; -.
DR EnsemblPlants; AT2G47620.1; AT2G47620.1; AT2G47620.
DR GeneID; 819375; -.
DR Gramene; AT2G47620.1; AT2G47620.1; AT2G47620.
DR KEGG; ath:AT2G47620; -.
DR Araport; AT2G47620; -.
DR TAIR; locus:2043263; AT2G47620.
DR eggNOG; KOG1279; Eukaryota.
DR HOGENOM; CLU_004447_5_1_1; -.
DR InParanoid; Q8W475; -.
DR OMA; MFISTTY; -.
DR OrthoDB; 683891at2759; -.
DR PhylomeDB; Q8W475; -.
DR PRO; PR:Q8W475; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8W475; baseline and differential.
DR Genevisible; Q8W475; AT.
DR GO; GO:0016514; C:SWI/SNF complex; ISS:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; ISS:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR032451; SMARCC_C.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF04433; SWIRM; 1.
DR Pfam; PF16495; SWIRM-assoc_1; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS50934; SWIRM; 1.
PE 1: Evidence at protein level;
KW Activator; Chromatin regulator; Coiled coil; Developmental protein;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..512
FT /note="SWI/SNF complex subunit SWI3A"
FT /id="PRO_0000344527"
FT DOMAIN 13..110
FT /note="SWIRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00247"
FT DOMAIN 223..274
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 291..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 424..488
FT /evidence="ECO:0000255"
FT COMPBIAS 297..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 512 AA; 57485 MW; 03E23ED31BC88AA4 CRC64;
MEATDPSAEI ELYTIPAQSS WFLWDDIHEI ERREFAEFFT ESSITRTPKV YKEYRDFIIN
KFREDTCRRL TFTSVRKFLV GDVNLLQKVF LFLEKWGLIN FSSSLKKNDH LLSVDNAKIE
QGTPAGIRVT ATPNSLRPIT APPLVEERVE TGIKVPPLTS YSDVFSDLKK PDHVLVCAHC
GERCDSPFYQ HNKGIVNICE KCFKNGNYGE NNTADDFKLI GNSAAAVWTE EEILLLLESV
LKHGDDWELI SQSVSTKSRL DCISKLIELP FGEFLMGSAS GRLNPSILTE DENTEQVQTD
GQEHEETETR EEKEDRVNED EPPAKRKRVA LISEGDSSLM KQVAAMASKV GPSVATAAAK
AALAALCDEA SCPKEIFDTD DYSNFTVDRA NGEKDTDMEE QQEEKDGPQG LPVALRIRAS
VATALGAAAA QAKILADQEE REMEQLAATV IEQQLKKLQS KLKFLDDLES IMDEEEKVIE
GVKETIIQER VSVLQCAFRS GITKRWDHTY VK
