SWI3C_ARATH
ID SWI3C_ARATH Reviewed; 807 AA.
AC Q9XI07;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=SWI/SNF complex subunit SWI3C;
DE Short=AtSWI3C;
DE AltName: Full=Transcription regulatory protein SWI3C;
GN Name=SWI3C; Synonyms=CHB4; OrderedLocusNames=At1g21700; ORFNames=F8K7.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INTERACTION WITH SWI3B.
RX PubMed=12140326; DOI=10.1093/nar/gkf458;
RA Sarnowski T.J., Swiezewski S., Pawlikowska K., Kaczanowski S.,
RA Jerzmanowski A.;
RT "AtSWI3B, an Arabidopsis homolog of SWI3, a core subunit of yeast Swi/Snf
RT chromatin remodeling complex, interacts with FCA, a regulator of flowering
RT time.";
RL Nucleic Acids Res. 30:3412-3421(2002).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14682613; DOI=10.1023/b:plan.0000004305.60407.8b;
RA Zhou C., Miki B., Wu K.;
RT "CHB2, a member of the SWI3 gene family, is a global regulator in
RT Arabidopsis.";
RL Plant Mol. Biol. 52:1125-1134(2003).
RN [6]
RP INTERACTION WITH BRM.
RX PubMed=15371304; DOI=10.1242/dev.01363;
RA Farrona S., Hurtado L., Bowman J.L., Reyes J.C.;
RT "The Arabidopsis thaliana SNF2 homolog AtBRM controls shoot development and
RT flowering.";
RL Development 131:4965-4975(2004).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH SWI3A AND BSH.
RX PubMed=16055636; DOI=10.1105/tpc.105.031203;
RA Sarnowski T.J., Rios G., Jasik J., Swiezewski S., Kaczanowski S., Li Y.,
RA Kwiatkowska A., Pawlikowska K., Kozbial M., Kozbial P., Koncz C.,
RA Jerzmanowski A.;
RT "SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play
RT distinct roles during Arabidopsis development.";
RL Plant Cell 17:2454-2472(2005).
RN [8]
RP INTERACTION WITH MORC6 AND SUVH9.
RX PubMed=27171427; DOI=10.1371/journal.pgen.1006026;
RA Liu Z.-W., Zhou J.-X., Huang H.-W., Li Y.-Q., Shao C.-R., Li L., Cai T.,
RA Chen S., He X.-J.;
RT "Two components of the RNA-Directed DNA methylation pathway associate with
RT MORC6 and silence loci targeted by MORC6 in Arabidopsis.";
RL PLoS Genet. 12:E1006026-E1006026(2016).
CC -!- FUNCTION: Component of a multiprotein complex equivalent of the SWI/SNF
CC complex, an ATP-dependent chromatin-remodeling complex, which is
CC required for the positive and negative regulation of gene expression of
CC a large number of genes. It changes chromatin structure by altering
CC DNA-histone contacts within a nucleosome, leading eventually to a
CC change in nucleosome position, thus facilitating or repressing binding
CC of gene-specific transcription factors. {ECO:0000269|PubMed:14682613,
CC ECO:0000269|PubMed:16055636}.
CC -!- SUBUNIT: Heterodimer. Interacts with SWI3A, SWI3B and BRM, but not with
CC BSH. Interacts with MORC6 and SUVH9 (PubMed:27171427).
CC {ECO:0000269|PubMed:12140326, ECO:0000269|PubMed:15371304,
CC ECO:0000269|PubMed:16055636, ECO:0000269|PubMed:27171427}.
CC -!- INTERACTION:
CC Q9XI07; Q84JG2: SWI3B; NbExp=4; IntAct=EBI-1102300, EBI-1102271;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers and
CC siliques. {ECO:0000269|PubMed:14682613}.
CC -!- DISRUPTION PHENOTYPE: Plants are viable but have alterations in leaf,
CC root and flower development, and are early flowering.
CC {ECO:0000269|PubMed:16055636}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC007727; AAD41423.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30144.1; -; Genomic_DNA.
DR EMBL; AY091026; AAM13847.1; -; mRNA.
DR EMBL; AY117245; AAM51320.1; -; mRNA.
DR PIR; D86350; D86350.
DR RefSeq; NP_173589.1; NM_102019.4.
DR AlphaFoldDB; Q9XI07; -.
DR BioGRID; 24013; 163.
DR DIP; DIP-37816N; -.
DR IntAct; Q9XI07; 4.
DR STRING; 3702.AT1G21700.1; -.
DR iPTMnet; Q9XI07; -.
DR PaxDb; Q9XI07; -.
DR PRIDE; Q9XI07; -.
DR ProteomicsDB; 226556; -.
DR EnsemblPlants; AT1G21700.1; AT1G21700.1; AT1G21700.
DR GeneID; 838774; -.
DR Gramene; AT1G21700.1; AT1G21700.1; AT1G21700.
DR KEGG; ath:AT1G21700; -.
DR Araport; AT1G21700; -.
DR TAIR; locus:2036942; AT1G21700.
DR eggNOG; KOG1279; Eukaryota.
DR HOGENOM; CLU_004447_4_1_1; -.
DR InParanoid; Q9XI07; -.
DR OMA; CFLQGRM; -.
DR OrthoDB; 683891at2759; -.
DR PhylomeDB; Q9XI07; -.
DR PRO; PR:Q9XI07; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XI07; baseline and differential.
DR Genevisible; Q9XI07; AT.
DR GO; GO:0016514; C:SWI/SNF complex; ISS:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006338; P:chromatin remodeling; ISS:TAIR.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR032451; SMARCC_C.
DR InterPro; IPR007526; SWIRM.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF04433; SWIRM; 1.
DR Pfam; PF16495; SWIRM-assoc_1; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS50934; SWIRM; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 1: Evidence at protein level;
KW Activator; Chromatin regulator; Coiled coil; Developmental protein;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..807
FT /note="SWI/SNF complex subunit SWI3C"
FT /id="PRO_0000344529"
FT DOMAIN 176..274
FT /note="SWIRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00247"
FT DOMAIN 398..449
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT ZN_FING 340..394
FT /note="ZZ-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 598..656
FT /evidence="ECO:0000255"
FT COMPBIAS 30..53
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 345
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 348
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 368
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 371
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ SEQUENCE 807 AA; 88250 MW; DAB17C104E4B287F CRC64;
MPASEDRRGK WKRKKRGGLS AARKPKQEEE DMEEEDEENN NNNNEEMDDV ENADELQQNG
GATPDPGLGI GEVVEDSGSR ISDFPAVVKR VVIRPHASVM AVVAAERAGL IGETRGQGSL
PALENISFGQ LQALSTVPAD SLDLERSDGS SSAYVISPPP IMDGEGVVKR FGDLVHVLPM
HSDWFAPNTV DRLERQVVPQ FFSGKSPNHT PESYMEFRNA IVSKYVENPE KTLTISDCQG
LVDGVDIEDF ARVFRFLDHW GIINYCATAQ SHPGPLRDVS DVREDTNGEV NVPSAALTSI
DSLIKFDKPN CRHKGGEVYS SLPSLDGDSP DLDIRIREHL CDSHCNHCSR PLPTVYFQSQ
KKGDILLCCD CFHHGRFVVG HSCLDFVRVD PMKFYGDQDG DNWTDQETLL LLEAVELYNE
NWVQIADHVG SKSKAQCILH FLRLPVEDGL LDNVEVSGVT NTENPTNGYD HKGTDSNGDL
PGYSEQGSDT EIKLPFVKSP NPVMALVAFL ASAVGPRVAA SCAHESLSVL SEDDRMKSEG
MQGKEASLLD GENQQQDGAH KTSSQNGAEA QTPLPQDKVM AAFRAGLSAA ATKAKLFADH
EEREIQRLSA NIVNHQLKRM ELKLKQFAEI ETLLMKECEQ VEKTRQRFSA ERARMLSARF
GSPGGISPQT NNLQGMSLST GGNNINSLMH QQHQQQQASA TSQPSIIPGF SNNPQVQAQM
HFMARQQQQQ QQQQQQQQQA FSFGPRLPLN AIQTNAGSTA SPNVMFGNNQ LNNPAAAGAA
SINQPSFSHP MVRSSTGSGS GSGLGLN
