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SWI4_YEAST
ID   SWI4_YEAST              Reviewed;        1093 AA.
AC   P25302; D3DM17;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 200.
DE   RecName: Full=Regulatory protein SWI4;
DE   AltName: Full=Cell-cycle box factor subunit SWI4;
DE   AltName: Full=Protein ART1;
GN   Name=SWI4; Synonyms=ART1; OrderedLocusNames=YER111C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2689885; DOI=10.1038/342830a0;
RA   Andrews B.J., Herskowitz I.;
RT   "The yeast SW14 protein contains a present in developmental regulators and
RT   is part of a complex involved in cell-cycle-dependent transcription.";
RL   Nature 342:830-833(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 845-1093.
RX   PubMed=8355657; DOI=10.1007/bf00277063;
RA   Daniel J.;
RT   "Potentially rapid walking in cellular regulatory networks using the gene-
RT   gene interference method in yeast.";
RL   Mol. Gen. Genet. 240:245-257(1993).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA   Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA   Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT   "Analysis of phosphorylation sites on proteins from Saccharomyces
RT   cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
RN   [7]
RP   INTERACTION WITH MSA2.
RX   PubMed=18160399; DOI=10.1074/jbc.m708248200;
RA   Ashe M., de Bruin R.A.M., Kalashnikova T., McDonald W.H., Yates J.R. III,
RA   Wittenberg C.;
RT   "The SBF- and MBF-associated protein Msa1 is required for proper timing of
RT   G1-specific transcription in Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 283:6040-6049(2008).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-806, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Part of a complex involved in cell-cycle-dependent
CC       transcription. SWI4 and SWI6 are required for formation of the cell-
CC       cycle box factor-DNA complex. The repeated element in the upstream
CC       region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
CC   -!- SUBUNIT: Component of the transcription complex SCB-binding factor
CC       (SBF) composed of SWI6 and SWI4. Interacts with MSA2.
CC       {ECO:0000269|PubMed:18160399}.
CC   -!- INTERACTION:
CC       P25302; P25302: SWI4; NbExp=4; IntAct=EBI-18626, EBI-18626;
CC       P25302; P09959: SWI6; NbExp=8; IntAct=EBI-18626, EBI-18641;
CC   -!- MISCELLANEOUS: Present with 589 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X51606; CAA35949.1; -; Genomic_DNA.
DR   EMBL; U18916; AAC03209.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07771.1; -; Genomic_DNA.
DR   PIR; S50614; S50614.
DR   RefSeq; NP_011036.1; NM_001179001.1.
DR   AlphaFoldDB; P25302; -.
DR   SMR; P25302; -.
DR   BioGRID; 36856; 656.
DR   ComplexPortal; CPX-946; SBF transcription complex.
DR   DIP; DIP-847N; -.
DR   IntAct; P25302; 77.
DR   MINT; P25302; -.
DR   STRING; 4932.YER111C; -.
DR   iPTMnet; P25302; -.
DR   MaxQB; P25302; -.
DR   PaxDb; P25302; -.
DR   PRIDE; P25302; -.
DR   EnsemblFungi; YER111C_mRNA; YER111C; YER111C.
DR   GeneID; 856847; -.
DR   KEGG; sce:YER111C; -.
DR   SGD; S000000913; SWI4.
DR   VEuPathDB; FungiDB:YER111C; -.
DR   eggNOG; ENOG502QUTG; Eukaryota.
DR   HOGENOM; CLU_009666_0_0_1; -.
DR   InParanoid; P25302; -.
DR   OMA; ELCLINT; -.
DR   BioCyc; YEAST:G3O-30275-MON; -.
DR   ChiTaRS; LDB19; yeast.
DR   PRO; PR:P25302; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P25302; protein.
DR   GO; GO:0000785; C:chromatin; IDA:SGD.
DR   GO; GO:0030907; C:MBF transcription complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR   GO; GO:0033309; C:SBF transcription complex; IDA:SGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:SGD.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:ComplexPortal.
DR   GO; GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IMP:SGD.
DR   GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:SGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:ComplexPortal.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036887; HTH_APSES_sf.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR029792; Swi4.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   PANTHER; PTHR43828:SF7; PTHR43828:SF7; 1.
DR   Pfam; PF04383; KilA-N; 1.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 2.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; DNA-binding; Phosphoprotein; Reference proteome; Repeat;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..1093
FT                   /note="Regulatory protein SWI4"
FT                   /id="PRO_0000067069"
FT   DOMAIN          37..147
FT                   /note="HTH APSES-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REPEAT          520..549
FT                   /note="ANK 1"
FT   REPEAT          641..670
FT                   /note="ANK 2"
FT   DNA_BIND        71..92
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REGION          138..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          973..1017
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..839
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1001..1017
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19779198"
FT   MOD_RES         806
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19779198"
FT   CONFLICT        175
FT                   /note="R -> T (in Ref. 1; CAA35949)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        431
FT                   /note="V -> I (in Ref. 1; CAA35949)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1054
FT                   /note="A -> L (in Ref. 1; CAA35949)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1093 AA;  123806 MW;  40EA2EA7732687A9 CRC64;
     MPFDVLISNQ KDNTNHQNIT PISKSVLLAP HSNHPVIEIA TYSETDVYEC YIRGFETKIV
     MRRTKDDWIN ITQVFKIAQF SKTKRTKILE KESNDMQHEK VQGGYGRFQG TWIPLDSAKF
     LVNKYEIIDP VVNSILTFQF DPNNPPPKRS KNSILRKTSP GTKITSPSSY NKTPRKKNSS
     SSTSATTTAA NKKGKKNASI NQPNPSPLQN LVFQTPQQFQ VNSSMNIMNN NDNHTTMNFN
     NDTRHNLINN ISNNSNQSTI IQQQKSIHEN SFNNNYSATQ KPLQFFPIPT NLQNKNVALN
     NPNNNDSNSY SHNIDNVINS SNNNNNGNNN NLIIVPDGPM QSQQQQQHHH EYLTNNFNHS
     MMDSITNGNS KKRRKKLNQS NEQQFYNQQE KIQRHFKLMK QPLLWQSFQN PNDHHNEYCD
     SNGSNNNNNT VASNGSSIEV FSSNENDNSM NMSSRSMTPF SAGNTSSQNK LENKMTDQEY
     KQTILTILSS ERSSDVDQAL LATLYPAPKN FNINFEIDDQ GHTPLHWATA MANIPLIKML
     ITLNANALQC NKLGFNCITK SIFYNNCYKE NAFDEIISIL KICLITPDVN GRLPFHYLIE
     LSVNKSKNPM IIKSYMDSII LSLGQQDYNL LKICLNYQDN IGNTPLHLSA LNLNFEVYNR
     LVYLGASTDI LNLDNESPAS IMNKFNTPAG GSNSRNNNTK ADRKLARNLP QKNYYQQQQQ
     QQQPQNNVKI PKIIKTQHPD KEDSTADVNI AKTDSEVNES QYLHSNQPNS TNMNTIMEDL
     SNINSFVTSS VIKDIKSTPS KILENSPILY RRRSQSISDE KEKAKDNENQ VEKKKDPLNS
     VKTAMPSLES PSSLLPIQMS PLGKYSKPLS QQINKLNTKV SSLQRIMGEE IKNLDNEVVE
     TESSISNNKK RLITIAHQIE DAFDSVSNKT PINSISDLQS RIKETSSKLN SEKQNFIQSL
     EKSQALKLAT IVQDEESKVD MNTNSSSHPE KQEDEEPIPK STSETSSPKN TKADAKFSNT
     VQESYDVNET LRLATELTIL QFKRRMTTLK ISEAKSKINS SVKLDKYRNL IGITIENIDS
     KLDDIEKDLR ANA
 
 
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