SWI5_HUMAN
ID SWI5_HUMAN Reviewed; 235 AA.
AC Q1ZZU3; Q5SYX7; Q5SYX8; Q8N2W6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=DNA repair protein SWI5 homolog;
DE AltName: Full=HBV DNAPTP1-transactivated protein A;
DE AltName: Full=Protein SAE3 homolog;
GN Name=SWI5; Synonyms=C9orf119, SAE3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lun Y.Z., Cheng J., Guo J., Zhang L.Y., Zhao B.C.;
RT "Homo sapiens HBV DNAPTP1-transactivated protein A.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-235.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, IDENTIFICATION IN THE SWI5-SFR1 COMPLEX, INTERACTION WITH RAD51,
RP AND MUTAGENESIS OF LEU-173.
RX PubMed=21252223; DOI=10.1074/jbc.m110.207290;
RA Yuan J., Chen J.;
RT "The role of human SWI5-MEI5 complex in homologous recombination repair.";
RL J. Biol. Chem. 286:9888-9893(2011).
RN [5]
RP INTERACTION WITH RAD51.
RX PubMed=23754376; DOI=10.1073/pnas.1220662110;
RA Yuan J., Chen J.;
RT "FIGNL1-containing protein complex is required for efficient homologous
RT recombination repair.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:10640-10645(2013).
CC -!- FUNCTION: Component of the SWI5-SFR1 complex, a complex required for
CC double-strand break repair via homologous recombination.
CC {ECO:0000269|PubMed:21252223}.
CC -!- SUBUNIT: Component of the SWI5-SFR1 complex. Interacts with RAD51.
CC {ECO:0000269|PubMed:21252223, ECO:0000269|PubMed:23754376}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SWI5/SAE3 family. {ECO:0000305}.
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DR EMBL; DQ414820; ABD72916.1; -; mRNA.
DR EMBL; AL590708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029911; AAH29911.1; -; mRNA.
DR RefSeq; NP_001035100.1; NM_001040011.1.
DR RefSeq; NP_001305018.1; NM_001318089.1.
DR RefSeq; NP_001305021.1; NM_001318092.1.
DR AlphaFoldDB; Q1ZZU3; -.
DR SMR; Q1ZZU3; -.
DR BioGRID; 131997; 3.
DR IntAct; Q1ZZU3; 1.
DR STRING; 9606.ENSP00000316609; -.
DR iPTMnet; Q1ZZU3; -.
DR PhosphoSitePlus; Q1ZZU3; -.
DR BioMuta; SWI5; -.
DR DMDM; 121940938; -.
DR EPD; Q1ZZU3; -.
DR jPOST; Q1ZZU3; -.
DR MassIVE; Q1ZZU3; -.
DR MaxQB; Q1ZZU3; -.
DR PaxDb; Q1ZZU3; -.
DR PeptideAtlas; Q1ZZU3; -.
DR PRIDE; Q1ZZU3; -.
DR ProteomicsDB; 61258; -.
DR DNASU; 375757; -.
DR GeneID; 375757; -.
DR KEGG; hsa:375757; -.
DR UCSC; uc004bup.4; human.
DR CTD; 375757; -.
DR DisGeNET; 375757; -.
DR GeneCards; SWI5; -.
DR HGNC; HGNC:31412; SWI5.
DR MIM; 616528; gene.
DR neXtProt; NX_Q1ZZU3; -.
DR PharmGKB; PA134903574; -.
DR eggNOG; ENOG502S8Z3; Eukaryota.
DR InParanoid; Q1ZZU3; -.
DR OrthoDB; 1553901at2759; -.
DR PhylomeDB; Q1ZZU3; -.
DR TreeFam; TF336078; -.
DR PathwayCommons; Q1ZZU3; -.
DR SignaLink; Q1ZZU3; -.
DR BioGRID-ORCS; 375757; 15 hits in 237 CRISPR screens.
DR ChiTaRS; SWI5; human.
DR GenomeRNAi; 375757; -.
DR Pharos; Q1ZZU3; Tdark.
DR PRO; PR:Q1ZZU3; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q1ZZU3; protein.
DR Genevisible; Q1ZZU3; HS.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032798; C:Swi5-Sfr1 complex; IDA:UniProtKB.
DR GO; GO:0034974; C:Swi5-Swi2 complex; IBA:GO_Central.
DR GO; GO:0071479; P:cellular response to ionizing radiation; IDA:UniProtKB.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
DR InterPro; IPR010760; DNA-repair_Swi5.
DR PANTHER; PTHR28529; PTHR28529; 1.
DR Pfam; PF07061; Swi5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..235
FT /note="DNA repair protein SWI5 homolog"
FT /id="PRO_0000324584"
FT REGION 139..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 156..183
FT /evidence="ECO:0000255"
FT MUTAGEN 173
FT /note="L->P: Does not affect interaction with SFR1/MEI5."
FT /evidence="ECO:0000269|PubMed:21252223"
SQ SEQUENCE 235 AA; 26739 MW; 5DCA1CE228987987 CRC64;
MQRRGQRDLW RHNKSCARNR CPRPPRERGG AGFPWVRAQL SVRQFTLRVR VPGPVHLRGR
SPTPALDPLA PLNPLIRGPR TPGLRRWIQS LALLLPNCSS SRIPTVPRPH SGLWVQSDFP
LGFLSRTEPR LTRSCRGAFR SPRPLPKSGQ ADGTSEESLH LDIQKLKEKR DMLDKEISQF
VSEGYSVDEL EDHITQLHEY NDIKDVGQML MGKLAVIRGV TTKELYPEFG LDMND
