SWI5_MOUSE
ID SWI5_MOUSE Reviewed; 89 AA.
AC Q8K3D3; A2AN41;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=DNA repair protein SWI5 homolog;
DE AltName: Full=Protein SAE3 homolog;
GN Name=Swi5; Synonyms=Sae3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, IDENTIFICATION IN THE
RP SWI5-SFR1 COMPLEX, SUBCELLULAR LOCATION, AND INTERACTION WITH RAD51.
RX PubMed=20976249; DOI=10.1371/journal.pgen.1001160;
RA Akamatsu Y., Jasin M.;
RT "Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
RT through homologous recombination.";
RL PLoS Genet. 6:E1001160-E1001160(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the SWI5-SFR1 complex, a complex required for
CC double-strand break repair via homologous recombination.
CC {ECO:0000269|PubMed:20976249}.
CC -!- SUBUNIT: Component of the SWI5-SFR1 complex. Interacts with RAD51.
CC {ECO:0000269|PubMed:20976249}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20976249}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K3D3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K3D3-2; Sequence=VSP_040899;
CC -!- SIMILARITY: Belongs to the SWI5/SAE3 family. {ECO:0000305}.
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DR EMBL; AB597964; BAJ25750.1; -; mRNA.
DR EMBL; AK013517; BAC25409.1; -; mRNA.
DR EMBL; AK166608; BAE38890.1; -; mRNA.
DR EMBL; AL808027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL08533.1; -; Genomic_DNA.
DR EMBL; BC021748; AAH21748.1; -; mRNA.
DR CCDS; CCDS50566.1; -. [Q8K3D3-1]
DR CCDS; CCDS71026.1; -. [Q8K3D3-2]
DR RefSeq; NP_001277481.1; NM_001290552.1. [Q8K3D3-2]
DR RefSeq; NP_780399.1; NM_175190.5. [Q8K3D3-1]
DR AlphaFoldDB; Q8K3D3; -.
DR SMR; Q8K3D3; -.
DR BioGRID; 215652; 1.
DR STRING; 10090.ENSMUSP00000057512; -.
DR iPTMnet; Q8K3D3; -.
DR PhosphoSitePlus; Q8K3D3; -.
DR EPD; Q8K3D3; -.
DR MaxQB; Q8K3D3; -.
DR PaxDb; Q8K3D3; -.
DR PeptideAtlas; Q8K3D3; -.
DR PRIDE; Q8K3D3; -.
DR ProteomicsDB; 254731; -. [Q8K3D3-1]
DR ProteomicsDB; 254732; -. [Q8K3D3-2]
DR Antibodypedia; 58850; 43 antibodies from 12 providers.
DR DNASU; 72931; -.
DR Ensembl; ENSMUST00000113395; ENSMUSP00000109022; ENSMUSG00000044627. [Q8K3D3-1]
DR Ensembl; ENSMUST00000113400; ENSMUSP00000109027; ENSMUSG00000044627. [Q8K3D3-2]
DR Ensembl; ENSMUST00000183946; ENSMUSP00000139299; ENSMUSG00000044627. [Q8K3D3-1]
DR GeneID; 72931; -.
DR KEGG; mmu:72931; -.
DR UCSC; uc008jet.3; mouse. [Q8K3D3-1]
DR UCSC; uc012bts.2; mouse. [Q8K3D3-2]
DR CTD; 375757; -.
DR MGI; MGI:1920181; Swi5.
DR VEuPathDB; HostDB:ENSMUSG00000044627; -.
DR eggNOG; ENOG502S8Z3; Eukaryota.
DR GeneTree; ENSGT00390000009349; -.
DR HOGENOM; CLU_106110_1_1_1; -.
DR InParanoid; Q8K3D3; -.
DR OMA; LMSEGYN; -.
DR OrthoDB; 1553901at2759; -.
DR PhylomeDB; Q8K3D3; -.
DR TreeFam; TF336078; -.
DR BioGRID-ORCS; 72931; 19 hits in 108 CRISPR screens.
DR ChiTaRS; Swi5; mouse.
DR PRO; PR:Q8K3D3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K3D3; protein.
DR Bgee; ENSMUSG00000044627; Expressed in secondary palatal shelf and 265 other tissues.
DR ExpressionAtlas; Q8K3D3; baseline and differential.
DR Genevisible; Q8K3D3; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0032798; C:Swi5-Sfr1 complex; IDA:UniProtKB.
DR GO; GO:0034974; C:Swi5-Swi2 complex; IBA:GO_Central.
DR GO; GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
DR InterPro; IPR010760; DNA-repair_Swi5.
DR PANTHER; PTHR28529; PTHR28529; 1.
DR Pfam; PF07061; Swi5; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA damage; DNA repair; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..89
FT /note="DNA repair protein SWI5 homolog"
FT /id="PRO_0000324585"
FT COILED 10..38
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MGSRGGTALTWGESEFSRLYHGGYRSPQRPFPM (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:20976249"
FT /id="VSP_040899"
FT MOD_RES Q8K3D3-2:26
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 89 AA; 10261 MW; AA0FA2E05F9DF60A CRC64;
MIDENNDVSE EALSSDIKKL KEKHDMLDKE ISQLIAEGYR VIELEKHISL LHEYNDIKDV
SQMLLGKLAV TRGVTTKELY PDFDLNLND
