SWI5_SCHPO
ID SWI5_SCHPO Reviewed; 85 AA.
AC Q9UUB7;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Mating-type switching protein swi5;
DE AltName: Full=DNA repair protein swi5;
GN Name=swi5; ORFNames=SPBC409.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH SFR1; SWI2 AND
RP RHP51.
RX PubMed=14663140; DOI=10.1073/pnas.2632890100;
RA Akamatsu Y., Dziadkowiec D., Ikeguchi M., Shinagawa H., Iwasaki H.;
RT "Two different Swi5-containing protein complexes are involved in mating-
RT type switching and recombination repair in fission yeast.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:15770-15775(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for normal mating-type switching. Also involved in
CC the rhp51-dependent recombination DNA repair pathway.
CC {ECO:0000269|PubMed:14663140}.
CC -!- SUBUNIT: Interacts with sfr1 and rhp51 during DNA repair. Interacts
CC with swi2 and rhp51 during mating-type switching.
CC {ECO:0000269|PubMed:14663140}.
CC -!- INTERACTION:
CC Q9UUB7; Q9USV1: sfr1; NbExp=17; IntAct=EBI-926902, EBI-927233;
CC Q9UUB7; Q10668: swi2; NbExp=5; IntAct=EBI-926902, EBI-926914;
CC Q9UUB7; Q9UUB7: swi5; NbExp=2; IntAct=EBI-926902, EBI-926902;
CC -!- SIMILARITY: Belongs to the SWI5/SAE3 family. {ECO:0000305}.
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DR EMBL; AB089498; BAC77071.1; -; Genomic_DNA.
DR EMBL; AB089499; BAC77072.1; -; mRNA.
DR EMBL; CU329671; CAB52605.1; -; Genomic_DNA.
DR PIR; T40431; T40431.
DR RefSeq; NP_595453.1; NM_001021363.2.
DR PDB; 3VIQ; X-ray; 2.20 A; B/D=1-85.
DR PDB; 3VIR; X-ray; 2.70 A; A/B/C/D=1-85.
DR PDBsum; 3VIQ; -.
DR PDBsum; 3VIR; -.
DR AlphaFoldDB; Q9UUB7; -.
DR SMR; Q9UUB7; -.
DR BioGRID; 277101; 25.
DR DIP; DIP-29233N; -.
DR IntAct; Q9UUB7; 56.
DR STRING; 4896.SPBC409.03.1; -.
DR MaxQB; Q9UUB7; -.
DR PaxDb; Q9UUB7; -.
DR EnsemblFungi; SPBC409.03.1; SPBC409.03.1:pep; SPBC409.03.
DR GeneID; 2540574; -.
DR KEGG; spo:SPBC409.03; -.
DR PomBase; SPBC409.03; swi5.
DR VEuPathDB; FungiDB:SPBC409.03; -.
DR eggNOG; ENOG502SBQH; Eukaryota.
DR HOGENOM; CLU_106110_3_1_1; -.
DR InParanoid; Q9UUB7; -.
DR OMA; TTVKRHI; -.
DR PhylomeDB; Q9UUB7; -.
DR PRO; PR:Q9UUB7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032798; C:Swi5-Sfr1 complex; IDA:PomBase.
DR GO; GO:0034974; C:Swi5-Swi2 complex; IPI:PomBase.
DR GO; GO:0001671; F:ATPase activator activity; IDA:PomBase.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000730; P:DNA recombinase assembly; IDA:PomBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IGI:PomBase.
DR GO; GO:0007534; P:gene conversion at mating-type locus; IMP:PomBase.
DR GO; GO:0007533; P:mating type switching; IMP:PomBase.
DR GO; GO:0010772; P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination; IDA:PomBase.
DR GO; GO:0000709; P:meiotic joint molecule formation; IDA:PomBase.
DR GO; GO:0000708; P:meiotic strand invasion; IDA:PomBase.
DR GO; GO:0062110; P:negative regulation of DNA recombinase disassembly; IDA:PomBase.
DR GO; GO:0042148; P:strand invasion; IDA:PomBase.
DR IDEAL; IID50105; -.
DR InterPro; IPR010760; DNA-repair_Swi5.
DR PANTHER; PTHR28529; PTHR28529; 1.
DR Pfam; PF07061; Swi5; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..85
FT /note="Mating-type switching protein swi5"
FT /id="PRO_0000072351"
FT HELIX 3..29
FT /evidence="ECO:0007829|PDB:3VIQ"
FT STRAND 32..34
FT /evidence="ECO:0007829|PDB:3VIQ"
FT HELIX 36..67
FT /evidence="ECO:0007829|PDB:3VIQ"
FT HELIX 72..75
FT /evidence="ECO:0007829|PDB:3VIQ"
FT HELIX 76..79
FT /evidence="ECO:0007829|PDB:3VIQ"
SQ SEQUENCE 85 AA; 9748 MW; DAA84500D8A84B71 CRC64;
MEKSQLESRV HLLEQQKEQL ESSLQDALAK LKNRDAKQTV QKHIDLLHTY NEIRDIALGM
IGKVAEHEKC TSVELFDRFG VNGSE
