SWI6_KLULA
ID SWI6_KLULA Reviewed; 769 AA.
AC P40418; Q6CUW2;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Regulatory protein SWI6;
DE AltName: Full=Cell-cycle box factor subunit SWI6;
DE AltName: Full=MBF subunit P90;
DE AltName: Full=Trans-acting activator of HO endonuclease gene;
GN Name=SWI6; OrderedLocusNames=KLLA0C01826g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8372350; DOI=10.1126/science.8372350;
RA Koch C., Moll T., Neuberg M., Ahorn H., Nasmyth K.;
RT "A role for the transcription factors Mbp1 and Swi4 in progression from G1
RT to S phase.";
RL Science 261:1551-1557(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Part of a complex involved in cell-cycle-dependent
CC transcription. SWI4 and SWI6 are required for formation of the cell-
CC cycle box factor-DNA complex. The repeated element in the upstream
CC region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB).
CC -!- SUBUNIT: MBF contains SWI6 and MBP1; SBF contains SWI6 and SWI4.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X74292; CAA52345.1; -; Genomic_DNA.
DR EMBL; CR382123; CAH01128.1; -; Genomic_DNA.
DR PIR; S36657; S36657.
DR RefSeq; XP_452277.1; XM_452277.1.
DR AlphaFoldDB; P40418; -.
DR SMR; P40418; -.
DR STRING; 28985.XP_452277.1; -.
DR PRIDE; P40418; -.
DR EnsemblFungi; CAH01128; CAH01128; KLLA0_C01826g.
DR GeneID; 2892682; -.
DR KEGG; kla:KLLA0_C01826g; -.
DR eggNOG; ENOG502QPWC; Eukaryota.
DR HOGENOM; CLU_017827_0_0_1; -.
DR InParanoid; P40418; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0030907; C:MBF transcription complex; IEA:EnsemblFungi.
DR GO; GO:0033309; C:SBF transcription complex; IEA:EnsemblFungi.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR GO; GO:0010845; P:positive regulation of reciprocal meiotic recombination; IEA:EnsemblFungi.
DR GO; GO:0061408; P:positive regulation of transcription from RNA polymerase II promoter in response to heat stress; IEA:EnsemblFungi.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:EnsemblFungi.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040822; Swi6_N.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF18530; Swi6_N; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW Activator; ANK repeat; DNA-binding; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..769
FT /note="Regulatory protein SWI6"
FT /id="PRO_0000067070"
FT REPEAT 286..315
FT /note="ANK 1"
FT REPEAT 422..451
FT /note="ANK 2"
FT REGION 94..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 655..682
FT /note="Missing (in Ref. 2; CAH01128)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 769 AA; 86670 MW; E3A5328B4DA084FB CRC64;
MSRPIFKVHK GDRITFQQRL QDGYVCLDQF IPLLTNLSSF NFHRDDPLVE NLDDMVTSQF
NILIDTDRSG TRWITLQKAH ELWDLLQIKD DSGSENLTDH DDDNEANHNG VEDDGQKTPE
NNGRKTDNHT MENGGTENTN NGNNSSNKND GNVTAEGSNF RPATITNGTT SRISGGEPDT
VKHELLDLPD SPTKRHQTKS VSKIPVFQHD LPTVSTLQKT LPPVSNYSND ERAKLETLLQ
RILFPETTNL NVAEGYPSVS LTQQVQELDT QFPNVPLNFN IPIDEHGNTS LHWLCSIANL
DLLKQLIVFG SDRRIGDKSG ESVLVKSVKS VNNYDSGTFE ILLDYLYPCI VMVDDMDRTV
LHHIVITSGM PGCNAAAKYY LDILMGWIVK KQSRTKESHC VLLEDIDLQW VITHLLNARD
SNGDTCLNIA ARLGNVAIVE ALLDYGADPN IANNSGLCPV DFGAGTQPRF QSNTKNLMAT
PTKTHETSLD PMAESTSLIT NIKSLLSKIS NDYGDEIKQH NGKMKELLDT LNIKREALAN
ARDRLAKAKQ IQDEYNLLSD RLNNVENTIA EEDQNFQLAS RELGLSLDDV QEEGLNSADI
AFDADEPFRI SYVYTKFEEK IKDEYNNDFE LFLKHCNLSQ LVHEIYDNFP SRAEIPHPKI
LKARIKAYNR NELHLDSTLQ TIIPHPKILK ARIKAYNRNE LHLDSTLQTI KDKQKNLESK
FRKVLSLCLK IDEEKVDSML DGLLQAISNE DPEDIDTDEV NNFLESAAE
