SWI6_MAGOR
ID SWI6_MAGOR Reviewed; 895 AA.
AC Q3S405;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Transcription factor SWI6 {ECO:0000303|PubMed:22321443};
GN Name=SWI6 {ECO:0000303|Ref.1};
OS Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=318829;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Guyane 11;
RA Cartwright Z.J., Talbot N.J.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH PPS1.
RX PubMed=22321443; DOI=10.1111/j.1364-3703.2011.00779.x;
RA Qi Z., Wang Q., Dou X., Wang W., Zhao Q., Lv R., Zhang H., Zheng X.,
RA Wang P., Zhang Z.;
RT "MoSwi6, an APSES family transcription factor, interacts with MoMps1 and is
RT required for hyphal and conidial morphogenesis, appressorial function and
RT pathogenicity of Magnaporthe oryzae.";
RL Mol. Plant Pathol. 13:677-689(2012).
CC -!- FUNCTION: Transcription factor that plays a role downstream of the
CC MCK1-MKK2-MPS1 cascade (PubMed:22321443). Required for hyphal
CC morphogenesis and pathogenicity (PubMed:22321443). Is an important
CC oxidative stress response regulator and plays a positive role in the
CC regulation of extracellular peroxidases (PubMed:22321443).
CC {ECO:0000269|PubMed:22321443}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:22321443}.
CC -!- DISRUPTION PHENOTYPE: Leads to deformed and non-melanized appressoria
CC that are unable to penetrate plant surface due to the impaired cell
CC wall integrity (PubMed:22321443). Shows abnormal hyphae as a result of
CC altered chitin synthesis (PubMed:22321443). Leads to sensitivity to
CC H(2)O(2) (PubMed:22321443). {ECO:0000269|PubMed:22321443}.
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DR EMBL; DQ168586; ABA02072.1; -; Genomic_DNA.
DR AlphaFoldDB; Q3S405; -.
DR SMR; Q3S405; -.
DR OMA; HHIAMMA; -.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:UniProt.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0000083; P:regulation of transcription involved in G1/S transition of mitotic cell cycle; IEA:UniProt.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Conidiation; Nucleus; Repeat; Sporulation;
KW Transcription; Transcription regulation; Virulence.
FT CHAIN 1..895
FT /note="Transcription factor SWI6"
FT /id="PRO_0000453105"
FT DOMAIN 112..219
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REPEAT 458..488
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 607..636
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT DNA_BIND 143..164
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 698..759
FT /evidence="ECO:0000255"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 895 AA; 97714 MW; AABE05BC8DD8412D CRC64;
MASTVAGNSF VSQQHPGNLH SANLQSQSQG FRRQNSTSSV PSTASFDPPN GSIANTGSQK
HHPMSSQQSQ PPASQQSFSM SQTGSQPQPS QSSFRSYSDQ NVPQQPQEAS PIYTAVYSNV
EVYEFEVNGV AVMKRIGDSK LNATQILKVA GVEKGKRTKI LEKEIQTGEH EKVQGGYGKY
QGTWIKYERA LEVCRQYGVE ELLRPLLEYN RNPDGSVSQA NLNTPTKEQA MAAQRKKMYN
SGADSRNNNG GGTFFKNISQ TAHSAMTAIS KARFDSPGPR GRNGPTRAPS FQRQLSTQSI
DDFHGGNSQA SNFAENFPPQ DVNMAFSAGS EPQPGGLNGT EPPRKRQRMD MTPANSFGAY
ANNSQMQAYA DAFPGSPTEP NDSFIYTQHA AANDTLLQQQ HDQQTPLQPL PYEQSVEAEN
KRSMLMSIFM NDGMSEQARV DTLRQIHPRD LDMPIDSQCH TALHWAATLS RMTILRRLIE
AGASPFRVNT SGETPLMRAC IVTNSHDNDS MPAILDILGN TMEVRDSKER TVLHHIALTS
AVSGRSAASR YYLQCLLGWV VRQGAANGGQ LNSQTFNGGA TVSQSQNATR LDLGRFMSEM
LNAQDSAGDT ALNIAARIGN RSIISQLLEV CASPHIANRS GLRPTDFGIG VDSDGAMKTK
GDSGGDVENG DVGGSSQKSN ESSNEIVTSI THLLTETSAN FQEEIKNKQK NIDSLHATLR
LTTTDVNDLR RKLDEAQARV KAQQLARQKV TNLQRAEERE RYRLTQLEQT TGRRDIASAN
GWEAESNTLL ATINATTNGE PDADAKLPSS ALLRARIEAV KKQTESTRQS VVALKGRSRE
VEGRYRHLVA LATKCRDEDV DSTMEGLLKA VESEKGELEI GRVRRFLGGV EGVIG
