SWM2_YEAST
ID SWM2_YEAST Reviewed; 146 AA.
AC P40342; D6W1I0; Q540B3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Nucleolar protein SWM2;
DE AltName: Full=Synthetic With MUD2-delta protein 2;
GN Name=SWM2; OrderedLocusNames=YNR004W; ORFNames=N2033;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CEN.PK 113-7D;
RX PubMed=14654430; DOI=10.1016/s1567-1356(03)00156-9;
RA Daran-Lapujade P., Daran J.-M., Koetter P., Petit T., Piper M.D.W.,
RA Pronk J.T.;
RT "Comparative genotyping of the Saccharomyces cerevisiae laboratory strains
RT S288C and CEN.PK113-7D using oligonucleotide microarrays.";
RL FEMS Yeast Res. 4:259-269(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7900425; DOI=10.1002/yea.320101013;
RA Verhasselt P., Aert R., Voet M., Volckaert G.;
RT "Twelve open reading frames revealed in the 23.6 kb segment flanking the
RT centromere on the Saccharomyces cerevisiae chromosome XIV right arm.";
RL Yeast 10:1355-1361(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP DISRUPTION PHENOTYPE.
RX PubMed=12489128; DOI=10.1002/yea.932;
RA Volckaert G., Voet M., Van der Schueren J., Robben J., Vanstreels E.,
RA Vander Stappen J.;
RT "Disruption of 12 ORFs located on chromosomes IV, VII and XIV of
RT Saccharomyces cerevisiae reveals two essential genes.";
RL Yeast 20:79-88(2003).
RN [9]
RP DISRUPTION PHENOTYPE.
RX PubMed=19466415; DOI=10.1007/s00294-009-0251-0;
RA Watanabe M., Watanabe D., Nogami S., Morishita S., Ohya Y.;
RT "Comprehensive and quantitative analysis of yeast deletion mutants
RT defective in apical and isotropic bud growth.";
RL Curr. Genet. 55:365-380(2009).
RN [10]
RP DISRUPTION PHENOTYPE.
RX PubMed=20360394; DOI=10.1261/rna.2082610;
RA Chang J., Schwer B., Shuman S.;
RT "Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2:
RT proteins implicated in pre-mRNA splicing.";
RL RNA 16:1018-1031(2010).
CC -!- INTERACTION:
CC P40342; Q12052: TGS1; NbExp=5; IntAct=EBI-28438, EBI-30910;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
CC -!- DISRUPTION PHENOTYPE: Leads to cold-sensitive growth and elongated
CC buds. Is synthetic lethal with a MUD2 deletant.
CC {ECO:0000269|PubMed:12489128, ECO:0000269|PubMed:19466415,
CC ECO:0000269|PubMed:20360394}.
CC -!- MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the SWM2 family. {ECO:0000305}.
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DR EMBL; AY222080; AAP06933.1; -; Genomic_DNA.
DR EMBL; X77395; CAA54573.1; -; Genomic_DNA.
DR EMBL; Z71619; CAA96280.1; -; Genomic_DNA.
DR EMBL; AY692584; AAT92603.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10546.1; -; Genomic_DNA.
DR PIR; S45128; S45128.
DR RefSeq; NP_014401.1; NM_001183181.1.
DR AlphaFoldDB; P40342; -.
DR BioGRID; 35830; 201.
DR DIP; DIP-1973N; -.
DR IntAct; P40342; 3.
DR MINT; P40342; -.
DR STRING; 4932.YNR004W; -.
DR MaxQB; P40342; -.
DR PaxDb; P40342; -.
DR PRIDE; P40342; -.
DR EnsemblFungi; YNR004W_mRNA; YNR004W; YNR004W.
DR GeneID; 855738; -.
DR KEGG; sce:YNR004W; -.
DR SGD; S000005287; SWM2.
DR VEuPathDB; FungiDB:YNR004W; -.
DR eggNOG; ENOG502S9UQ; Eukaryota.
DR HOGENOM; CLU_147530_0_0_1; -.
DR InParanoid; P40342; -.
DR OMA; NAVRICE; -.
DR BioCyc; YEAST:G3O-33323-MON; -.
DR PRO; PR:P40342; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P40342; protein.
DR GO; GO:0005730; C:nucleolus; HDA:SGD.
DR GO; GO:0036261; P:7-methylguanosine cap hypermethylation; IMP:SGD.
DR GO; GO:0008033; P:tRNA processing; IMP:SGD.
DR InterPro; IPR031391; Swm2.
DR Pfam; PF17083; Swm2; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome.
FT CHAIN 1..146
FT /note="Nucleolar protein SWM2"
FT /id="PRO_0000203468"
SQ SEQUENCE 146 AA; 17097 MW; 29C8BE6F0720DB53 CRC64;
MIDLYNYSNL EGLLDGLTDL NRIPKEYSAV LEPYFQNIAR NAHLKSRALK ICRSNFHKWN
EEGAKTVNPE IIRRCLNLWY VLKGKEYKKL KDPPPADNII KDEIDVSYVK NLNVVRLEFD
EFGKLISNPL ENLILEEVEV NDFIQE
