ID   SWNT_ARTBC              Reviewed;         498 AA.
AC   D4AU27;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Swainsonine transporter swnT {ECO:0000303|PubMed:28381497};
DE   AltName: Full=Swainsonine biosynthesis gene cluster protein T {ECO:0000303|PubMed:28381497};
GN   Name=swnT {ECO:0000303|PubMed:28381497}; ORFNames=ARB_07840;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   IDENTIFICATION, AND PATHWAY.
RX   PubMed=28381497; DOI=10.1534/g3.117.041384;
RA   Cook D., Donzelli B.G., Creamer R., Baucom D.L., Gardner D.R., Pan J.,
RA   Moore N., Jaromczyk J.W., Schardl C.L.;
RT   "Swainsonine biosynthesis genes in diverse symbiotic and pathogenic
RT   fungi.";
RL   G3 (Bethesda) 7:1791-1797(2017).
CC   -!- FUNCTION: Transmembrane transporter; part of the gene cluster that
CC       mediates the biosynthesis of swainsonine, a cytotoxic fungal alkaloid
CC       and a potential cancer therapy drug (PubMed:28381497). Does not mediate
CC       the secretion of SW and the exact role of swnT in SW biosynthesis
CC       remains to be determined (By similarity).
CC       {ECO:0000250|UniProtKB:E9F8M0, ECO:0000269|PubMed:28381497}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.
CC       {ECO:0000305}.
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DR   EMBL; ABSU01000010; EFE33480.1; -; Genomic_DNA.
DR   RefSeq; XP_003014120.1; XM_003014074.1.
DR   AlphaFoldDB; D4AU27; -.
DR   SMR; D4AU27; -.
DR   STRING; 663331.D4AU27; -.
DR   EnsemblFungi; EFE33480; EFE33480; ARB_07840.
DR   GeneID; 9521537; -.
DR   KEGG; abe:ARB_07840; -.
DR   eggNOG; KOG1289; Eukaryota.
DR   HOGENOM; CLU_004495_2_4_1; -.
DR   OMA; PFWYPKL; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   Pfam; PF13520; AA_permease_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="Swainsonine transporter swnT"
FT                   /id="PRO_0000441191"
FT   TRANSMEM        42..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        242
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   498 AA;  54221 MW;  37922F45F4F72DCB CRC64;
     MSLRNDEQTE KGAVVGKVDS QLSGPGQEEI IQVQTQKPFT TLSAIGIGYG VTNTAVGLLL
     VLGTGIPMGG SPVIFWGFLA MAAVGLATAT TLSELISAIP HPGGQYIWVH KIAPERYRRG
     LSYATAMISW IAAIAIGASG NLAVPVNAFT IVTLLNPNFV YQRWMGFVVF QLINIVTCFG
     ACFEYFLPKI SKALLLVNVL SVSAIIITLF ATAKTHTSAK DFFKVVNVSG WPNGVAFLIG
     LNGSNWCFSC LDVATHLAEE IPSPSTNIPK ALIWTIVIAF SSGLLMILAV LVNVGPINTP
     DYSGLTVLHH ITGSKAAAIG LWVPVLFLVF ASVWSIQTWQ SRLAWSISRE SGFPLHRHFS
     KIFPAPFYTP IWSLIGSAIG TALFGCLYLA SELAFNSLIA TGILLQYASY SIPTILVLYR
     GRSKFQHGPF WYPKLGFMAN IVMLAWTLVA LIFYCFPVYS EVIPSQVNYV SAVLILIAIL
     ITSLWFLYAK KHYHVVEI