ID   SWP26_NOSB1             Reviewed;         223 AA.
AC   B9UJ97; R0MHW8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2013, sequence version 2.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Spore wall protein 26;
DE   Flags: Precursor;
GN   Name=SWP26; ORFNames=NBO_60g0001;
OS   Nosema bombycis (strain CQ1 / CVCC 102059) (Microsporidian parasite)
OS   (Pebrine of silkworm).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nosematidae; Nosema.
OX   NCBI_TaxID=578461;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION BY MASS SPECTROMETRY,
RP   FUNCTION, DOMAIN, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=CQ1 / CVCC 102059;
RX   PubMed=18854188; DOI=10.1016/j.ijpara.2008.08.011;
RA   Li Y., Wu Z., Pan G., He W., Zhang R., Hu J., Zhou Z.;
RT   "Identification of a novel spore wall protein (SWP26) from microsporidia
RT   Nosema bombycis.";
RL   Int. J. Parasitol. 39:391-398(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQ1 / CVCC 102059;
RX   PubMed=23496955; DOI=10.1186/1471-2164-14-186;
RA   Pan G., Xu J., Li T., Xia Q., Liu S.L., Zhang G., Li S., Li C., Liu H.,
RA   Yang L., Liu T., Zhang X., Wu Z., Fan W., Dang X., Xiang H., Tao M., Li Y.,
RA   Hu J., Li Z., Lin L., Luo J., Geng L., Wang L., Long M., Wan Y., He N.,
RA   Zhang Z., Lu C., Keeling P.J., Wang J., Xiang Z., Zhou Z.;
RT   "Comparative genomics of parasitic silkworm microsporidia reveal an
RT   association between genome expansion and host adaptation.";
RL   BMC Genomics 14:186-186(2013).
CC   -!- FUNCTION: Spore wall protein involved in the adhesion to host cells
CC       surface. Microsporidian spore adherence is an integral part of
CC       activation and host cell invasion which requires the extrusion at the
CC       spore apex of a very long and coiled structure, the polar tube, through
CC       which the sporoplasm is pushed to enter into the potential host cell.
CC       {ECO:0000269|PubMed:18854188}.
CC   -!- SUBCELLULAR LOCATION: Spore core {ECO:0000269|PubMed:18854188}. Spore
CC       wall {ECO:0000269|PubMed:18854188}. Spore, perispore
CC       {ECO:0000269|PubMed:18854188}.
CC   -!- DEVELOPMENTAL STAGE: Synthesized during sporogony.
CC       {ECO:0000269|PubMed:18854188}.
CC   -!- DOMAIN: Heparin-binding motifs (HBMs) are characterized by an XBBXBX or
CC       XBBBXXBX sequence, where X is any neutral amino acid and B is a
CC       positively charged basic amino acid, and are defined as the consensus
CC       sequence necessary for protein-heparin interactions. The HBM motif is
CC       involved in spore adherence to host cells.
CC       {ECO:0000269|PubMed:18854188}.
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DR   EMBL; EU677842; ACG56269.1; -; Genomic_DNA.
DR   EMBL; KB908968; EOB13745.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9UJ97; -.
DR   EnsemblFungi; EOB13745; EOB13745; NBO_60g0001.
DR   VEuPathDB; MicrosporidiaDB:NBO_60g0001; -.
DR   HOGENOM; CLU_1240447_0_0_1; -.
DR   Proteomes; UP000016927; Unassembled WGS sequence.
DR   GO; GO:0031160; C:spore wall; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell adhesion; Reference proteome; Signal; Sporulation.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..223
FT                   /note="Spore wall protein 26"
FT                   /id="PRO_0000385181"
FT   MOTIF           207..214
FT                   /note="HBM"
FT   CONFLICT        142
FT                   /note="A -> T (in Ref. 1; ACG56269)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   223 AA;  25706 MW;  EF6AE52B8E69D71A CRC64;
     MNIIIFSLMT ISFLRARFGY EKEILPMMDT ASDKSYLQGP PNPYTATVNP LERLISDTYL
     KVTGILSHYF AYYQENVAEF RRWFQSIYYE MDDDTRKKIL NELNLNLRSM DDLENFWTET
     QGAILKGNLL ELSDLLKGLE EAVNAKTHMS SEANNDLIKS KINFKDKAVD FLNQLNKIYG
     FLDLGLSYHT SNRFTDVHAM FLDAAASKKK LDKSFESISG IDD