ID   SWRAA_BACSU             Reviewed;         117 AA.
AC   O32266;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Swarming motility protein SwrAA;
GN   Name=swrAA; Synonyms=swrA; OrderedLocusNames=BSU35230;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DETERMINATION OF THE TRANSLATIONAL START
RP   SITE, AND IDENTIFICATION OF THE FRAMESHIFTED PROTEIN IN LABORATORY STRAINS.
RC   STRAIN=168, 168 / PY79, and 3610;
RX   PubMed=15066026; DOI=10.1111/j.1365-2958.2004.03996.x;
RA   Kearns D.B., Chu F., Rudner R., Losick R.;
RT   "Genes governing swarming in Bacillus subtilis and evidence for a phase
RT   variation mechanism controlling surface motility.";
RL   Mol. Microbiol. 52:357-369(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16030230; DOI=10.1128/jb.187.15.5356-5366.2005;
RA   Calvio C., Celandroni F., Ghelardi E., Amati G., Salvetti S., Ceciliani F.,
RA   Galizzi A., Senesi S.;
RT   "Swarming differentiation and swimming motility in Bacillus subtilis are
RT   controlled by swrA, a newly identified dicistronic operon.";
RL   J. Bacteriol. 187:5356-5366(2005).
CC   -!- FUNCTION: Required for swarm cell differentiation. Plays a crucial role
CC       in regulating the degree of cell flagellation.
CC       {ECO:0000269|PubMed:16030230}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16030230}.
CC   -!- MISCELLANEOUS: This protein is functional in undomesticated strains of
CC       B.subtilis but not in laboratory strains, such as 168, because of a
CC       frameshift mutation. Therefore laboratory strains of B.subtilis are
CC       unable to swarm.
CC   -!- MISCELLANEOUS: The frameshift in strain 168 is caused by a single
CC       insertion of an adenine in the codon for Tyr-12 which leads to the
CC       premature truncation of the protein in residue 13. In addition, the C-
CC       terminal section of swrAA was predicted to be an ORF (yvzD) by the
CC       genome project.
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DR   EMBL; AL009126; CAB15540.1; ALT_SEQ; Genomic_DNA.
DR   PIR; H70049; H70049.
DR   AlphaFoldDB; O32266; -.
DR   SMR; O32266; -.
DR   PaxDb; O32266; -.
DR   PRIDE; O32266; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:1900192; P:positive regulation of single-species biofilm formation; IMP:CACAO.
DR   InterPro; IPR035388; SwrA.
DR   Pfam; PF17423; SwrA; 1.
PE   4: Predicted;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..117
FT                   /note="Swarming motility protein SwrAA"
FT                   /id="PRO_0000072353"
FT   VARIANT         69
FT                   /note="M -> A (in strain: 3610)"
SQ   SEQUENCE   117 AA;  13897 MW;  E271AC74FE518CD6 CRC64;
     MKRASIVREK KYYELVEQLK DRTQDVTFSA TKALSLLMLF SRYLVNYTNV ESVNDINEEC
     AKHYFNYLMK NHKRLGINLT DIKRSMHLIS GLLDVDVNHY LKDFSLSNVT LWMTQER