ID   SWRC_BACSU              Reviewed;        1052 AA.
AC   O31501;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Swarming motility protein SwrC;
GN   Name=swrC; OrderedLocusNames=BSU06710;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   ROLE IN SURFACTIN RESISTANCE, AND DETERMINATION OF THE TRANSCRIPTIONAL
RP   START SITE.
RC   STRAIN=168;
RX   PubMed=11709341; DOI=10.1128/aac.45.12.3566-3573.2001;
RA   Tsuge K., Ohata Y., Shoda M.;
RT   "Gene yerP, involved in surfactin self-resistance in Bacillus subtilis.";
RL   Antimicrob. Agents Chemother. 45:3566-3573(2001).
RN   [3]
RP   ROLE IN SWARMING MOTILITY.
RC   STRAIN=168, 168 / PY79, and 3610;
RX   PubMed=15066026; DOI=10.1111/j.1365-2958.2004.03996.x;
RA   Kearns D.B., Chu F., Rudner R., Losick R.;
RT   "Genes governing swarming in Bacillus subtilis and evidence for a phase
RT   variation mechanism controlling surface motility.";
RL   Mol. Microbiol. 52:357-369(2004).
CC   -!- FUNCTION: Required for self-resistance to surfactin, an antimicrobial
CC       lipopeptide surfactant produced by B.subtilis. Also required for
CC       swarming motility. {ECO:0000269|PubMed:11709341,
CC       ECO:0000269|PubMed:15066026}.
CC   -!- INTERACTION:
CC       O31501; P96706: ydgH; NbExp=3; IntAct=EBI-5242442, EBI-5242915;
CC       O31501; O07523: yhaP; NbExp=4; IntAct=EBI-5242442, EBI-5242593;
CC       O31501; O34755: ykoT; NbExp=4; IntAct=EBI-5242442, EBI-5242987;
CC       O31501; P45920: yqbD; NbExp=3; IntAct=EBI-5242442, EBI-5242682;
CC       O31501; P96722: ywqJ; NbExp=3; IntAct=EBI-5242442, EBI-5243080;
CC   -!- INDUCTION: Not induced by surfactin.
CC   -!- MISCELLANEOUS: A SwrC-deficient strain is susceptible to acriflavine
CC       and ethidium bromide, and showed severer growth inhibition as surfactin
CC       concentration increased up to 100ug/ml.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000305}.
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DR   EMBL; AL009126; CAB12491.2; -; Genomic_DNA.
DR   PIR; E69795; E69795.
DR   RefSeq; NP_388553.1; NC_000964.3.
DR   RefSeq; WP_003242663.1; NZ_JNCM01000032.1.
DR   AlphaFoldDB; O31501; -.
DR   SMR; O31501; -.
DR   IntAct; O31501; 63.
DR   STRING; 224308.BSU06710; -.
DR   jPOST; O31501; -.
DR   PaxDb; O31501; -.
DR   PRIDE; O31501; -.
DR   EnsemblBacteria; CAB12491; CAB12491; BSU_06710.
DR   GeneID; 938055; -.
DR   KEGG; bsu:BSU06710; -.
DR   PATRIC; fig|224308.179.peg.729; -.
DR   eggNOG; COG0841; Bacteria.
DR   InParanoid; O31501; -.
DR   OMA; WRGVRTD; -.
DR   BioCyc; BSUB:BSU06710-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2090.10; -; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Reference proteome.
FT   CHAIN           1..1052
FT                   /note="Swarming motility protein SwrC"
FT                   /id="PRO_0000161847"
SQ   SEQUENCE   1052 AA;  113505 MW;  3272825F07A238D0 CRC64;
     MNHVINFVLK NKFAVWLMTI IVTAAGLYAG MNMKQESIPD VNMPYLTIST TYPGATPSQV
     ADEVTKPVEQ AVQNLDGVSV VTSTSYENAS SVMIEYDYEK DMDKAKTEAA EALENVNLPD
     DAKDPEISRY SLNSFPILTL SVSSDKDNLQ ELTKQVEDSL VSKLEGIEGV ASVQVSGQQV
     EEVEFSFKED KLKEYGLDED TVKQVIQGSD VTTPLGLYTF GNEEKSVVVS GDIETIKDLK
     NMRIPTASAS SAGSSAASQA GAQSAQAAQS AQAAAQVQQS ASTAVPTVKL SDIATIKDVK
     KAESVSRTNG KDSIGINIVK ANDANTVEVA DDVKAELKKF KEDHKGFNYS ATLDMAEPIT
     QSVDTMLSKA IFGAIFAIVI ILLFLRDIKS TLISVVSIPL SLLIALLVLQ QLDITLNIMT
     LGAMTVAIGR VVDDSIVVIE NIYRRMRLKD EPLRGKALVR EATKEMFKPI MSSTIVTIAV
     FLPLALVGGQ IGELFIPFAL TIVFALAASL VISITLVPML AHSLFKKSLT GAPIKAKEHK
     PGRLANIYKK VLNWALSHKW ITSIIAVLML LGSLFLVPLI GASYLPSEEE KTMQLTYSPE
     PGETKKEAEN EAEKAEKILL DRKHVDTVQY SLGSGSPLAG GDSNGALFYI KYESDTPDFD
     KEKDNVLKEI QKQSDRGEWK SQDFSSSGNN NELTYYVYGD SENDIKDTVK DIEKIMKDEK
     DLKNVNSGLS STYDEYTFVA DQEKLSKLGL TASQISQALM SQTSQEPLTT VKKDGKELDV
     NIKTEKDEYK SVKDLENKKI TSATGQEVKI GDVAKVKEGS TSDTVSKRDG KVYADVTGEV
     TSDNVTAVSA AIQKKIDKLD HPDNVSIDTG GVSADIADSF TKLGLAMLAA IAIVYLVLVI
     TFGGALAPFA ILFSLPFTVI GALVGLYVSG ETISLNAMIG MLMLIGIVVT NAIVLIDRVI
     HKEAEGLSTR EALLEAGSTR LRPILMTAIA TIGALIPLAL GFEGGSQVIS KGLGVTVIGG
     LISSTLLTLL IVPIVYEVLA KFRKKKPGTE EE