ID   SWRI_SERLI              Reviewed;         200 AA.
AC   P52989;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein SwrI;
GN   Name=swrI;
OS   Serratia liquefaciens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MG1;
RX   PubMed=8861211; DOI=10.1111/j.1365-2958.1996.tb02495.x;
RA   Eberl L., Winson M.K., Sternberg C., Stewart G.S.A.B., Christiansen G.,
RA   Chhebra S.R., Bycroft B., Williams P., Molin S., Givskov M.;
RT   "Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling
RT   the multicellular behaviour of Serratia liquefaciens.";
RL   Mol. Microbiol. 20:127-136(1996).
CC   -!- FUNCTION: Required for the synthesis of BHL (N-butanoyl-L-homoserine
CC       lactone).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; U22823; AAB18141.1; -; Genomic_DNA.
DR   PIR; S71036; S71036.
DR   AlphaFoldDB; P52989; -.
DR   SMR; P52989; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..200
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210897"
SQ   SEQUENCE   200 AA;  23542 MW;  1BE18B58AA8C6AE2 CRC64;
     MIELFDVDYN LLPDNRSKEL FSLRKKTFKD RLDWLVNCEN NMEFDEYDNR HATYIFGTYQ
     NHVICSLRFI ETKYPNMISD GVFDTYFNDI KLPDGNYVEA SRLFIDKARI QALQLHQAPI
     SAMLFLSMIN YARNCGYEGI YAIISHPMRI IFQRSGWHIS VVKTGCSEKN KNIYLIYMPI
     DDANRNRLLA RINQHATKMG