SWS1_SCHPO
ID SWS1_SCHPO Reviewed; 209 AA.
AC O13600;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Zinc finger SWIM domain-containing protein sws1;
DE AltName: Full=SWIM domain-containing and srs2-interacting protein 1;
GN Name=sws1; ORFNames=pi005, SPACTOKYO_453.32, SPBC11B10.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, INTERACTION WITH RDL1; RLP1 AND SRS2, SUBCELLULAR LOCATION, AND
RP MUTAGENESIS OF CYS-152.
RX PubMed=16710300; DOI=10.1038/sj.emboj.7601141;
RA Martin V., Chahwan C., Gao H., Blais V., Wohlschlegel J., Yates J.R. III,
RA McGowan C.H., Russell P.;
RT "Sws1 is a conserved regulator of homologous recombination in eukaryotic
RT cells.";
RL EMBO J. 25:2564-2574(2006).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in early stages of the homologous recombination
CC repair (HRR) pathway of double-stranded DNA breaks arising during DNA
CC replication or induced by DNA-damaging agents.
CC {ECO:0000269|PubMed:16710300}.
CC -!- SUBUNIT: Interacts with rdl1, rlp1 and srs2.
CC {ECO:0000269|PubMed:16710300}.
CC -!- INTERACTION:
CC O13600; O13800: rdl1; NbExp=2; IntAct=EBI-8527040, EBI-8527164;
CC O13600; O74331: rlp1; NbExp=2; IntAct=EBI-8527040, EBI-8527133;
CC O13600; Q10213: srs2; NbExp=2; IntAct=EBI-8527040, EBI-8527058;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm.
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DR EMBL; AB004534; BAA21382.1; -; Genomic_DNA.
DR EMBL; CU329671; CAC37510.1; -; Genomic_DNA.
DR RefSeq; NP_595626.1; NM_001021520.2.
DR AlphaFoldDB; O13600; -.
DR BioGRID; 276510; 9.
DR IntAct; O13600; 4.
DR MINT; O13600; -.
DR STRING; 4896.SPBC11B10.06.1; -.
DR PaxDb; O13600; -.
DR EnsemblFungi; SPBC11B10.06.1; SPBC11B10.06.1:pep; SPBC11B10.06.
DR PomBase; SPBC11B10.06; sws1.
DR VEuPathDB; FungiDB:SPBC11B10.06; -.
DR HOGENOM; CLU_1338199_0_0_1; -.
DR InParanoid; O13600; -.
DR OMA; SSIGDIW; -.
DR PRO; PR:O13600; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005654; C:nucleoplasm; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0097196; C:Shu complex; ISO:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000725; P:recombinational repair; IMP:PomBase.
DR InterPro; IPR007527; Znf_SWIM.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA damage; DNA recombination; DNA repair; Metal-binding;
KW Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..209
FT /note="Zinc finger SWIM domain-containing protein sws1"
FT /id="PRO_0000223107"
FT ZN_FING 143..203
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 152
FT /note="C->S: MMS sensitive; reduced zinc chelation."
FT /evidence="ECO:0000269|PubMed:16710300"
SQ SEQUENCE 209 AA; 23525 MW; 84E25390F75C18AC CRC64;
MQQGHFTSNS YHSKTLNSSS LPVSSKFSHT NDPDVEGVDN DSFSKALCNK DLDPSSTIRS
VISSLLDSLQ DKALQQSPNT SLSKLLLEDQ DFGSLWLSLS FIFCNYWQPA MLILDSKSIH
PLPLTDGEVL HRWECEVDSN NKTTIDLKYW YCSCSQFSYN AFNSSRSFDE PMPKNEQETW
GGRCLSHHPT ICSHILAASI LRACHNLVI
