SWT13_ARATH
ID SWT13_ARATH Reviewed; 294 AA.
AC Q9FGQ2; Q8LAZ2;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Bidirectional sugar transporter SWEET13 {ECO:0000303|PubMed:21107422};
DE Short=AtSWEET13 {ECO:0000303|PubMed:21107422};
DE AltName: Full=Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 13 {ECO:0000303|PubMed:21107422};
GN Name=SWEET13 {ECO:0000303|PubMed:21107422}; OrderedLocusNames=At5g50800;
GN ORFNames=K7B16.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INDUCTION BY PATHOGENS, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=22157085; DOI=10.1126/science.1213351;
RA Chen L.-Q., Qu X.-Q., Hou B.-H., Sosso D., Osorio S., Fernie A.R.,
RA Frommer W.B.;
RT "Sucrose efflux mediated by SWEET proteins as a key step for phloem
RT transport.";
RL Science 335:207-211(2012).
RN [6]
RP INTERACTION WITH SWEET1; SWEET3; SWEET6; SWEET7; SWEET8; SWEET9; SWEET11
RP AND SWEET17.
RX PubMed=24027245; DOI=10.1073/pnas.1311244110;
RA Xuan Y.H., Hu Y.B., Chen L.-Q., Sosso D., Ducat D.C., Hou B.-H.,
RA Frommer W.B.;
RT "Functional role of oligomerization for bacterial and plant SWEET sugar
RT transporter family.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E3685-E3685(2013).
RN [7]
RP REVIEW.
RC STRAIN=cv. Columbia;
RX PubMed=25988582; DOI=10.1016/j.pbi.2015.04.005;
RA Eom J.-S., Chen L.-Q., Sosso D., Julius B.T., Lin I.W., Qu X.-Q.,
RA Braun D.M., Frommer W.B.;
RT "SWEETs, transporters for intracellular and intercellular sugar
RT translocation.";
RL Curr. Opin. Plant Biol. 25:53-62(2015).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane. Involved in nurturing the male gametophyte
CC (PubMed:25988582). {ECO:0000269|PubMed:22157085,
CC ECO:0000303|PubMed:25988582}.
CC -!- SUBUNIT: Forms heterooligomers with SWEET1, SWEET3, SWEET6, SWEET7,
CC SWEET8, SWEET9, SWEET11 and SWEET17. {ECO:0000269|PubMed:24027245}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in leaves.
CC {ECO:0000269|PubMed:22157085}.
CC -!- INDUCTION: Slightly induced by the fungal pathogen B.cinerea.
CC {ECO:0000269|PubMed:21107422}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AB025617; BAB08903.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95993.1; -; Genomic_DNA.
DR EMBL; AY087516; AAM65058.1; -; mRNA.
DR RefSeq; NP_199893.1; NM_124458.2.
DR PDB; 5XPD; X-ray; 2.79 A; A=1-222.
DR PDBsum; 5XPD; -.
DR AlphaFoldDB; Q9FGQ2; -.
DR SMR; Q9FGQ2; -.
DR BioGRID; 20398; 8.
DR STRING; 3702.AT5G50800.1; -.
DR TCDB; 2.A.123.1.26; the sweet, pq-loop, saliva, mtn3 (sweet) family.
DR PaxDb; Q9FGQ2; -.
DR PRIDE; Q9FGQ2; -.
DR ProteomicsDB; 226768; -.
DR EnsemblPlants; AT5G50800.1; AT5G50800.1; AT5G50800.
DR GeneID; 835152; -.
DR Gramene; AT5G50800.1; AT5G50800.1; AT5G50800.
DR KEGG; ath:AT5G50800; -.
DR Araport; AT5G50800; -.
DR TAIR; locus:2157951; AT5G50800.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_4_0_1; -.
DR InParanoid; Q9FGQ2; -.
DR OMA; FYIWATD; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9FGQ2; -.
DR PRO; PR:Q9FGQ2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGQ2; baseline and differential.
DR Genevisible; Q9FGQ2; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:1905201; F:gibberellin transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0008515; F:sucrose transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0009901; P:anther dehiscence; IGI:TAIR.
DR GO; GO:0052543; P:callose deposition in cell wall; IGI:TAIR.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:1905200; P:gibberellic acid transmembrane transport; IDA:TAIR.
DR GO; GO:0009555; P:pollen development; IGI:TAIR.
DR GO; GO:0080112; P:seed growth; IGI:TAIR.
DR GO; GO:0015770; P:sucrose transport; IDA:TAIR.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Repeat;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..294
FT /note="Bidirectional sugar transporter SWEET13"
FT /id="PRO_0000404113"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 10..97
FT /note="MtN3/slv 1"
FT DOMAIN 133..216
FT /note="MtN3/slv 2"
FT REGION 273..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 122
FT /note="E -> Z (in Ref. 3; AAM65058)"
FT /evidence="ECO:0000305"
FT HELIX 7..24
FT /evidence="ECO:0007829|PDB:5XPD"
FT TURN 25..27
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 28..37
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 46..65
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 68..70
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 71..92
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 96..108
FT /evidence="ECO:0007829|PDB:5XPD"
FT TURN 109..111
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 112..124
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 127..144
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 147..159
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 167..186
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 190..213
FT /evidence="ECO:0007829|PDB:5XPD"
FT HELIX 220..222
FT /evidence="ECO:0007829|PDB:5XPD"
SQ SEQUENCE 294 AA; 32504 MW; 26D88F65398D0DAE CRC64;
MALTNNLWAF VFGILGNIIS FVVFLAPVPT FVRICKKKST EGFQSLPYVS ALFSAMLWIY
YAMQKDGTAF LLITINAFGC VIETIYIVLF VSYANKKTRI STLKVLGLLN FLGFAAIVLV
CELLTKGSTR EKVLGGICVG FSVSVFAAPL SIMRVVVRTR SVEFMPFSLS LFLTISAVTW
LFYGLAIKDF YVALPNVLGA FLGAVQMILY IIFKYYKTPV AQKTDKSKDV SDHSIDIAKL
TTVIPGAVLD SAVHQPPALH NVPETKIQLT EVKSQNMTDP KDQINKDVQK QSQV
