SWT14_ARATH
ID SWT14_ARATH Reviewed; 281 AA.
AC Q9SW25;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Bidirectional sugar transporter SWEET14 {ECO:0000303|PubMed:21107422};
DE Short=AtSWEET14 {ECO:0000303|PubMed:21107422};
DE AltName: Full=Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 14 {ECO:0000303|PubMed:21107422};
GN Name=SWEET14 {ECO:0000303|PubMed:21107422}; OrderedLocusNames=At4g25010;
GN ORFNames=F13M23.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21107422; DOI=10.1038/nature09606;
RA Chen L.-Q., Hou B.-H., Lalonde S., Takanaga H., Hartung M.L., Qu X.-Q.,
RA Guo W.-J., Kim J.-G., Underwood W., Chaudhuri B., Chermak D., Antony G.,
RA White F.F., Somerville S.C., Mudgett M.B., Frommer W.B.;
RT "Sugar transporters for intercellular exchange and nutrition of
RT pathogens.";
RL Nature 468:527-532(2010).
RN [4]
RP FUNCTION.
RX PubMed=22157085; DOI=10.1126/science.1213351;
RA Chen L.-Q., Qu X.-Q., Hou B.-H., Sosso D., Osorio S., Fernie A.R.,
RA Frommer W.B.;
RT "Sucrose efflux mediated by SWEET proteins as a key step for phloem
RT transport.";
RL Science 335:207-211(2012).
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the plasma membrane. {ECO:0000269|PubMed:22157085}.
CC -!- SUBUNIT: Forms homooligomers and/or heterooligomers.
CC {ECO:0000250|UniProtKB:Q8L9J7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000305}.
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DR EMBL; AL035523; CAB36743.1; -; Genomic_DNA.
DR EMBL; AL161562; CAB79410.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE84991.1; -; Genomic_DNA.
DR PIR; T05522; T05522.
DR RefSeq; NP_194231.1; NM_118633.2.
DR AlphaFoldDB; Q9SW25; -.
DR SMR; Q9SW25; -.
DR STRING; 3702.AT4G25010.1; -.
DR PaxDb; Q9SW25; -.
DR PRIDE; Q9SW25; -.
DR ProteomicsDB; 226781; -.
DR EnsemblPlants; AT4G25010.1; AT4G25010.1; AT4G25010.
DR GeneID; 828604; -.
DR Gramene; AT4G25010.1; AT4G25010.1; AT4G25010.
DR KEGG; ath:AT4G25010; -.
DR Araport; AT4G25010; -.
DR TAIR; locus:2117263; AT4G25010.
DR eggNOG; KOG1623; Eukaryota.
DR HOGENOM; CLU_048643_4_2_1; -.
DR InParanoid; Q9SW25; -.
DR OMA; VIFKYYK; -.
DR OrthoDB; 1116261at2759; -.
DR PhylomeDB; Q9SW25; -.
DR PRO; PR:Q9SW25; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SW25; baseline and differential.
DR Genevisible; Q9SW25; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:1905201; F:gibberellin transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0008515; F:sucrose transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; ISS:UniProtKB.
DR GO; GO:0009901; P:anther dehiscence; IGI:TAIR.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:1905200; P:gibberellic acid transmembrane transport; IDA:TAIR.
DR GO; GO:0080112; P:seed growth; IGI:TAIR.
DR GO; GO:0015770; P:sucrose transport; IDA:TAIR.
DR InterPro; IPR004316; SWEET_sugar_transpr.
DR Pfam; PF03083; MtN3_slv; 2.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Repeat; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..281
FT /note="Bidirectional sugar transporter SWEET14"
FT /id="PRO_0000404114"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..70
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 11..97
FT /note="MtN3/slv 1"
FT DOMAIN 133..216
FT /note="MtN3/slv 2"
FT REGION 244..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 281 AA; 30969 MW; D01DA26449AC9B92 CRC64;
MVLTHNVLAV TFGVLGNIIS FIVFLAPVPT FVRICKKKSI EGFESLPYVS ALFSAMLWIY
YALQKDGAGF LLITINAVGC FIETIYIILF ITYANKKARI STLKVLGLLN FLGFAAIILV
CELLTKGSNR EKVLGGICVG FSVCVFAAPL SIMRVVIRTK SVEFMPFSLS LFLTISAITW
LFYGLAIKDF YVALPNILGA FLGAVQMILY VIFKYYKTPL VVDETEKPKT VSDHSINMVK
LSSTPASGDL TVQPQTNPDV SHPIKTHGGD LEDQMDKKMP N
