ID   SWT1A_SORBI             Reviewed;         269 AA.
AC   P0DKJ3;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Bidirectional sugar transporter SWEET1a {ECO:0000305};
DE            Short=SbSWEET1a {ECO:0000305};
GN   Name=SWEET1A {ECO:0000305}; OrderedLocusNames=Sb03g041740 {ECO:0000305};
OS   Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX   NCBI_TaxID=4558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BTx623;
RX   PubMed=19189423; DOI=10.1038/nature07723;
RA   Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA   Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA   Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA   Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA   Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA   Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA   Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman M.,
RA   Ware D., Westhoff P., Mayer K.F.X., Messing J., Rokhsar D.S.;
RT   "The Sorghum bicolor genome and the diversification of grasses.";
RL   Nature 457:551-556(2009).
CC   -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC       the plasma membrane. {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SUBUNIT: Forms homooligomers and/or heterooligomers.
CC       {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
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DR   EMBL; CM000762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DKJ3; -.
DR   SMR; P0DKJ3; -.
DR   STRING; 4558.Sb03g041740.1; -.
DR   EnsemblPlants; KXG33819; KXG33819; SORBI_3003G377700.
DR   Gramene; KXG33819; KXG33819; SORBI_3003G377700.
DR   eggNOG; KOG1623; Eukaryota.
DR   OMA; KLWISIE; -.
DR   OrthoDB; 1116261at2759; -.
DR   Proteomes; UP000000768; Chromosome 3.
DR   ExpressionAtlas; P0DKJ3; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   InterPro; IPR018180; SWEET1a.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   PANTHER; PTHR10791:SF155; PTHR10791:SF155; 1.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..269
FT                   /note="Bidirectional sugar transporter SWEET1a"
FT                   /id="PRO_0000434108"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        7..27
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..42
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        43..63
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..72
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        73..93
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..100
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..129
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        130..150
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        190..210
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..269
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          8..96
FT                   /note="MtN3/slv 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          132..215
FT                   /note="MtN3/slv 2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  29078 MW;  F8AA0ABEAAECED34 CRC64;
     MEHIARFFFG VSGNVIALFL FLSPVVTFWR IIRKRSTEDF SGVPYNMTLL NCLLSAWYGL
     PFVSPNNILV STINGTGSVI EAIYVVIFLI FAVDRRARLR MLGLLSIVVS IFATVVLVSL
     LALHGNARKV FCGLAATIFS ICMYASPLSI MRLVIKTKSV EYMPFLLSLA VFLCGTSWFI
     YGLLGRDPFI IIPNGCGSFL GLVQLILYFI YRKNKGPAVP AGKGEAAAAA DVEDAKKVAA
     AVEMADATTT NKAAADTVVG DGKVVASQV