SWT1_HUMAN
ID SWT1_HUMAN Reviewed; 900 AA.
AC Q5T5J6; Q8NEK9; Q9BZQ7; Q9NXQ0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Transcriptional protein SWT1;
GN Name=SWT1; Synonyms=C1orf26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11318611; DOI=10.1006/geno.2001.6500;
RA Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M.,
RA Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H.,
RA Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M.,
RA Carpten J.D.;
RT "Cloning and characterization of 13 novel transcripts and the human RGS8
RT gene from the 1q25 region encompassing the hereditary prostate cancer
RT (HPC1) locus.";
RL Genomics 73:211-222(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-148; ARG-536 AND
RP ASP-821.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 613-900.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- TISSUE SPECIFICITY: Expressed weakly in testis.
CC {ECO:0000269|PubMed:11318611}.
CC -!- SIMILARITY: Belongs to the SWT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90960.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF288392; AAG60612.1; -; mRNA.
DR EMBL; AL136133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030781; AAH30781.1; -; mRNA.
DR EMBL; AK000128; BAA90960.1; ALT_INIT; mRNA.
DR CCDS; CCDS1367.1; -.
DR RefSeq; NP_001098988.1; NM_001105518.1.
DR RefSeq; NP_060143.4; NM_017673.6.
DR RefSeq; XP_016857016.1; XM_017001527.1.
DR AlphaFoldDB; Q5T5J6; -.
DR SMR; Q5T5J6; -.
DR BioGRID; 120178; 4.
DR IntAct; Q5T5J6; 1.
DR STRING; 9606.ENSP00000356470; -.
DR GlyGen; Q5T5J6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5T5J6; -.
DR PhosphoSitePlus; Q5T5J6; -.
DR BioMuta; SWT1; -.
DR DMDM; 74745081; -.
DR MassIVE; Q5T5J6; -.
DR MaxQB; Q5T5J6; -.
DR PaxDb; Q5T5J6; -.
DR PeptideAtlas; Q5T5J6; -.
DR PRIDE; Q5T5J6; -.
DR ProteomicsDB; 64524; -.
DR Antibodypedia; 20611; 65 antibodies from 16 providers.
DR DNASU; 54823; -.
DR Ensembl; ENST00000367500.9; ENSP00000356470.4; ENSG00000116668.13.
DR Ensembl; ENST00000367501.7; ENSP00000356471.3; ENSG00000116668.13.
DR GeneID; 54823; -.
DR KEGG; hsa:54823; -.
DR MANE-Select; ENST00000367500.9; ENSP00000356470.4; NM_017673.7; NP_060143.4.
DR UCSC; uc001grg.5; human.
DR CTD; 54823; -.
DR DisGeNET; 54823; -.
DR GeneCards; SWT1; -.
DR HGNC; HGNC:16785; SWT1.
DR HPA; ENSG00000116668; Tissue enriched (testis).
DR MIM; 619513; gene.
DR neXtProt; NX_Q5T5J6; -.
DR OpenTargets; ENSG00000116668; -.
DR PharmGKB; PA25613; -.
DR VEuPathDB; HostDB:ENSG00000116668; -.
DR eggNOG; KOG4689; Eukaryota.
DR GeneTree; ENSGT00390000001254; -.
DR HOGENOM; CLU_015080_0_0_1; -.
DR InParanoid; Q5T5J6; -.
DR OMA; PWIVVQE; -.
DR OrthoDB; 1225441at2759; -.
DR PhylomeDB; Q5T5J6; -.
DR TreeFam; TF335526; -.
DR PathwayCommons; Q5T5J6; -.
DR BioGRID-ORCS; 54823; 11 hits in 1078 CRISPR screens.
DR ChiTaRS; SWT1; human.
DR GenomeRNAi; 54823; -.
DR Pharos; Q5T5J6; Tbio.
DR PRO; PR:Q5T5J6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T5J6; protein.
DR Bgee; ENSG00000116668; Expressed in sperm and 155 other tissues.
DR ExpressionAtlas; Q5T5J6; baseline and differential.
DR Genevisible; Q5T5J6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..900
FT /note="Transcriptional protein SWT1"
FT /id="PRO_0000251184"
FT DOMAIN 388..515
FT /note="PINc"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 148
FT /note="I -> V (in dbSNP:rs10489579)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027652"
FT VARIANT 536
FT /note="H -> R (in dbSNP:rs6698109)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027653"
FT VARIANT 638
FT /note="L -> F (in dbSNP:rs2295950)"
FT /id="VAR_027654"
FT VARIANT 821
FT /note="N -> D (in dbSNP:rs12041704)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027655"
FT CONFLICT 430
FT /note="L -> V (in Ref. 1; AAG60612)"
FT /evidence="ECO:0000305"
FT CONFLICT 571
FT /note="N -> S (in Ref. 3; AAH30781)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 900 AA; 103222 MW; 9ED199DFDD4094C7 CRC64;
MSSKESCGKK ETSQRKDTTT SSPNFGEKDK KERKTPASST SSSSIRSVSS EKRKLKSDHT
DVLYYNIKRR QGLKRLSVEI DTLRRRPKIG SSSQRPIKLK EASYSNDNQI ILQSPSSNGT
KKDIHKCVDF KPKDIKLTNA GSKLDHGIKS LSSPKIASDV KPKAEGQASE NKWSHLLVQR
EKMKELKKGR NSKFRDNSEK CVLEKWKRNQ FSQDYNSNKI IKEPLGSRRQ KISFKIPIKS
RDTLQKLVEE NVFNIDSNNS KTKQEEREYL ESSQVSLNVT RQKTEHLLSD FTYKRTVHEW
KRKHHYDHQE SNDSHSRENL TQSFEAPCCS VSSESIQDAD QEMQIVEELH AARVGKSVDL
PGELMSMEID LEDDVHSSSA NNTSDRKLLI VIDTNILMNH LKFVRILKTT EVPGFDKLVL
IIPWVVMQEL DRMKEGKLLK RAQHKAIPAV HFINDSLKNQ DRKLWGQSIQ LASQKHYGLS
DENNDDRVLK CCLQHQELFP CSFVILCTDD RNLRNKGLIS GVKSLSKEEL SAELLHLSLN
TDVCHQPCIP KQQLKAETTP LKESYKEEST NSGLSILLES IVSDLEKSLG TGLSSILETE
MKIAFGNLWM EILYLKPPWT LLHLLQCFKK HWLAVFGLVM EKNLLLTIES LYKNLRKANK
AVDFTTVKFL LQDSRSLLHA FSTRSNYDGI LPQTFAQVNN LLQTFAEVKT KLKPNSSENT
VTKKQEGTSL KNSHNQEITV FSSSHLPQPS RHQEIWSILE SVWITIYQNS TDVFQRLGSN
SALTTSNIAS FEEAFICLQK LMAAVRDILE GIQRILAPNS NYQDVETLYN FLIKYEVNKN
VKFTAQEIYD CVSQTEYREK LTIGCRQLVE MEYTMQQCNA SVYMEAKNRG WCEDMLNYRI
