SWT1_MOUSE
ID SWT1_MOUSE Reviewed; 907 AA.
AC Q9DBQ9; E9QP79; Q6PAN2; Q7TMQ6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transcriptional protein SWT1;
GN Name=Swt1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J, and FVB/N-3; TISSUE=Fetal brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9DBQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DBQ9-2; Sequence=VSP_020736;
CC Name=3;
CC IsoId=Q9DBQ9-3; Sequence=VSP_020734, VSP_020735;
CC -!- SIMILARITY: Belongs to the SWT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH60204.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK004803; BAB23575.2; -; mRNA.
DR EMBL; AC165946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055064; AAH55064.1; -; mRNA.
DR EMBL; BC060204; AAH60204.1; ALT_FRAME; mRNA.
DR CCDS; CCDS15360.1; -. [Q9DBQ9-1]
DR RefSeq; NP_080095.3; NM_025819.4. [Q9DBQ9-1]
DR AlphaFoldDB; Q9DBQ9; -.
DR SMR; Q9DBQ9; -.
DR STRING; 10090.ENSMUSP00000067516; -.
DR iPTMnet; Q9DBQ9; -.
DR PhosphoSitePlus; Q9DBQ9; -.
DR EPD; Q9DBQ9; -.
DR jPOST; Q9DBQ9; -.
DR PaxDb; Q9DBQ9; -.
DR PRIDE; Q9DBQ9; -.
DR ProteomicsDB; 254702; -. [Q9DBQ9-1]
DR ProteomicsDB; 254703; -. [Q9DBQ9-2]
DR ProteomicsDB; 254704; -. [Q9DBQ9-3]
DR Antibodypedia; 20611; 65 antibodies from 16 providers.
DR DNASU; 66875; -.
DR Ensembl; ENSMUST00000064771; ENSMUSP00000067516; ENSMUSG00000052748. [Q9DBQ9-1]
DR Ensembl; ENSMUST00000111883; ENSMUSP00000107514; ENSMUSG00000052748. [Q9DBQ9-3]
DR GeneID; 66875; -.
DR KEGG; mmu:66875; -.
DR UCSC; uc007cyq.2; mouse. [Q9DBQ9-1]
DR CTD; 54823; -.
DR MGI; MGI:1914125; Swt1.
DR VEuPathDB; HostDB:ENSMUSG00000052748; -.
DR eggNOG; KOG4689; Eukaryota.
DR GeneTree; ENSGT00390000001254; -.
DR HOGENOM; CLU_015080_0_0_1; -.
DR InParanoid; Q9DBQ9; -.
DR OMA; PWIVVQE; -.
DR OrthoDB; 1225441at2759; -.
DR PhylomeDB; Q9DBQ9; -.
DR TreeFam; TF335526; -.
DR BioGRID-ORCS; 66875; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Swt1; mouse.
DR PRO; PR:Q9DBQ9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9DBQ9; protein.
DR Bgee; ENSMUSG00000052748; Expressed in spermatid and 234 other tissues.
DR ExpressionAtlas; Q9DBQ9; baseline and differential.
DR Genevisible; Q9DBQ9; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..907
FT /note="Transcriptional protein SWT1"
FT /id="PRO_0000251185"
FT DOMAIN 395..522
FT /note="PINc"
FT REGION 30..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 665..679
FT /note="ANKAVDFTTVKFLLQ -> GQDKTEAKFFRKHKE (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020734"
FT VAR_SEQ 680..907
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020735"
FT VAR_SEQ 771
FT /note="M -> MSIYQNSISVFISDTVTFNLVAV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020736"
FT CONFLICT 84
FT /note="Y -> D (in Ref. 3; AAH55064)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="G -> V (in Ref. 3; AAH55064)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 907 AA; 103168 MW; 6AE62AD3D1F6F4A6 CRC64;
MLLCTTSAHK LETVYDHKFL KMSIKESCAK EEKSQKKQTI SSPTFNEDKK KGEISAGSTS
SEHGVQPVST KKRKLKADDT DNVYYNANRK NSKRLNVEVF IPKKRLKFSS STQAVSYLNN
NQMTSHSCSS NGTKDTKVKD CKLTNIGSKL NYEIKNHSRI KITKDMKSKP VDQTKEKNWP
SLLIQKKMKE LKKEKNNKDS SEELEKCKKN HLPQNYNFSN MIKESFESGR KKISFKIPKK
SSTTLQKLVE EKIFTIDSSK SKSKQEEKQH LQSHQMSLNL ARHKTENSFS DSTHKQSVCE
RIRKDHCEHQ GTSSSDSKEN HAQSFETPCS SVSSEDTQDA DEEMQIVEEL HAARVGRSVD
LPVVPPSGEL MSMEIDLVDE DAHPSAAHTA SDTKLLIVMD TNVLMNHLKF VKILKTTEIP
GFDTLVLIIP WVVIQELDRM KAGKLLKHVQ HKAVPAIHFI NNSLKSQDRK LWGQSLQLAS
QKLYGLSDEN NDDRVLKCCL QYQQLFPCSL VILCTDDRNL RTKGLISGVK SLSKEDLDTE
ILNLTLNTDL CHQPCISKQQ LNAEVPPAKE TPKEGAANSG LSILLERIIC DLEKCLGTAL
SSILETEMKI AFGNLWMEVL YLKPPWTLIN LLQCFKKHWL AVFGLVMENN LLVTVESLYE
NLCKANKAVD FTTVKFLLQD SKSLLHAFST RSNYDGVLPQ TFAQVNKLLQ VLAEVKTKLK
PSSSESTRSK EQEDTSLVKL HNQDVNVFLD SNLPQATRHQ EIWSVLESVW MSIYQNSTDV
FQTLDSSSTL TTSKIASFEE AFVYLQKLMV AVKDILEGIQ RILAPNSNYQ DVETLYNFLI
KYEVNKNVKF TARELYDCVS QTEYRERLTI GCRQLIEMEC TMQQCSASVY MEARSRGWCE
DMLNNRP
