ID   SWT21_KLULA             Reviewed;         411 AA.
AC   Q6CRJ7;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein SWT21;
GN   Name=SWT21; OrderedLocusNames=KLLA0D08514g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5'
CC       splice site interaction (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with snRNPs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWT21 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00538.1; -; Genomic_DNA.
DR   RefSeq; XP_453442.1; XM_453442.1.
DR   AlphaFoldDB; Q6CRJ7; -.
DR   STRING; 28985.XP_453442.1; -.
DR   EnsemblFungi; CAH00538; CAH00538; KLLA0_D08514g.
DR   GeneID; 2892901; -.
DR   KEGG; kla:KLLA0_D08514g; -.
DR   eggNOG; ENOG502QVPI; Eukaryota.
DR   HOGENOM; CLU_662333_0_0_1; -.
DR   InParanoid; Q6CRJ7; -.
DR   OMA; DYGIRQY; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..411
FT                   /note="Protein SWT21"
FT                   /id="PRO_0000405684"
SQ   SEQUENCE   411 AA;  47205 MW;  E33ED544D4A08256 CRC64;
     MQTIASTLDC YYGTNCNSLW SLEEELSRKF SAYAKNYEFP KLHRSYFHSV ERYCPVICSQ
     LTWSHDGTSI CGVFDDFGIR QYLIPEDPLV DHWVPFTRWF VNGSIISSVV HPRYSLYEED
     SAYQTILCSS RDLPIKLYSL RSDSINETSL YHYSTVNEEN EAFETAYSMT ILQDTMHFMT
     GSVRNRITMY DYNRHKPIWQ HQWTKQSCGK SSQKAIVSCF DEYNEVHDNV RFAGTYKTEV
     LRIDTRSTKS ELISERDSLD SWSNGIYQVI KSDNGHYLYC IKRNAREIDV IDTRMLKSRI
     NILELPFKIG KQKFKASLNS AKGLLIGSYD GQVACWDKDC IEFGGLDPLQ TAGTGIKPTN
     NILISDENVR VNCIATNPVD PNTLAISTST DKFADDEGMT LKTSVKLIRM H