ID   SWT21_LACTC             Reviewed;         422 AA.
AC   C5DD02;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Protein SWT21;
GN   Name=SWT21; OrderedLocusNames=KLTH0B07216g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5'
CC       splice site interaction (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with snRNPs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWT21 family. {ECO:0000305}.
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DR   EMBL; CU928166; CAR21663.1; -; Genomic_DNA.
DR   RefSeq; XP_002552101.1; XM_002552055.1.
DR   AlphaFoldDB; C5DD02; -.
DR   STRING; 559295.C5DD02; -.
DR   EnsemblFungi; CAR21663; CAR21663; KLTH0B07216g.
DR   GeneID; 8290941; -.
DR   KEGG; lth:KLTH0B07216g; -.
DR   eggNOG; ENOG502QVPI; Eukaryota.
DR   HOGENOM; CLU_662333_0_0_1; -.
DR   InParanoid; C5DD02; -.
DR   OMA; DYGIRQY; -.
DR   OrthoDB; 934297at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   SUPFAM; SSF50998; SSF50998; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..422
FT                   /note="Protein SWT21"
FT                   /id="PRO_0000405685"
SQ   SEQUENCE   422 AA;  47406 MW;  21BAB69D1E8992C7 CRC64;
     MNRVRKVYDT LDTFDGRDVL QSWKREGSRW LDQVENSTYQ FPELESSNYE RTKGRVPTEH
     IDLRSPIICT KLSWSQDGTS LVAVFNDYGV RQYLLPEEEG TGLVPFKRFF RAQPAVDCCI
     HPEYSLFNDS DACNVMLASS RDLPIQLLSL SPHAREHRPL FSYSVVNAEN ERFETMFSLS
     FSHYSGFLAG TSRNKVVAYD LNYKSPIWSS DGYGKPLRGT SARRAIISCF DSPSDSESVL
     RYAGTYRCDI YGIDLRTKEL NFLANKQTLE LKENSAGVAE LLFSVNKHYL YVIKRNSQTI
     DVLDARSSFA KINELYLSFR IGSQKIIATL DLINGLLIGT HDGKILQWAS NMVEFGGLLP
     RTPEGPAKDS AVSKVFDTSY AGSRINILAS SPSNPHLIAG SFSPDKFEAD HTAKSGLFVV
     DL