ID   SWT21_VANPO             Reviewed;         426 AA.
AC   A7TL79;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein SWT21;
GN   Name=SWT21; ORFNames=Kpol_1041p12;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5'
CC       splice site interaction (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with snRNPs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SWT21 family. {ECO:0000305}.
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DR   EMBL; DS480413; EDO16954.1; -; Genomic_DNA.
DR   RefSeq; XP_001644812.1; XM_001644762.1.
DR   AlphaFoldDB; A7TL79; -.
DR   STRING; 436907.A7TL79; -.
DR   EnsemblFungi; EDO16954; EDO16954; Kpol_1041p12.
DR   GeneID; 5545139; -.
DR   KEGG; vpo:Kpol_1041p12; -.
DR   eggNOG; ENOG502QVPI; Eukaryota.
DR   HOGENOM; CLU_662333_0_0_1; -.
DR   InParanoid; A7TL79; -.
DR   OMA; DYGIRQY; -.
DR   OrthoDB; 934297at2759; -.
DR   PhylomeDB; A7TL79; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..426
FT                   /note="Protein SWT21"
FT                   /id="PRO_0000405691"
SQ   SEQUENCE   426 AA;  48332 MW;  5488B21A4ADB6D5E CRC64;
     MNDKQRWYTL SSTANTFNGA NLNIVWDKEN TYWSKLASTS SYPYPKLNDS KYCNELGNLN
     KLDICQDLYW SADGTSLVAI NDDYGIRQYL IPESENCDNE SMLVPFTRTF SPRSIIASAL
     SPTYSLFNEN RSGNMLLISG RDVPLQSYQL DTDSTSCSKP SMTYNTLNDK IERYDIIFSM
     IFINSSQFIT GSVNNKISLY DVRRKEPVVS FDRFKREQSS SKRKSIISCF IDRANIDCNN
     RYPNIVYFGT YGREMGVVDK RMASQRRLLN FQHGNGVYQI LPSFNGHFLY ILHRSSNTID
     IVDVRKDNKV INQLRIPYKI GTQKMKGTLS ETNGLMLGTD YGSVINWQSD MIEFGGLASD
     GSIVKDYQQS VSECLTSFTG SRINIVQQCP QGNEYFAISY SPDKFSDSDK TSAVKSGISL
     LRASID