ID   SWT2A_SORBI             Reviewed;         243 AA.
AC   P0DKJ4;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Bidirectional sugar transporter SWEET2a {ECO:0000305};
DE            Short=SbSWEET2a {ECO:0000305};
GN   Name=SWEET2A {ECO:0000305}; OrderedLocusNames=Sb03g024250 {ECO:0000305};
OS   Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX   NCBI_TaxID=4558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. BTx623;
RX   PubMed=19189423; DOI=10.1038/nature07723;
RA   Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA   Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA   Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA   Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA   Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA   Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA   Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman M.,
RA   Ware D., Westhoff P., Mayer K.F.X., Messing J., Rokhsar D.S.;
RT   "The Sorghum bicolor genome and the diversification of grasses.";
RL   Nature 457:551-556(2009).
CC   -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC       the plasma membrane. {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SUBUNIT: Forms homooligomers and/or heterooligomers.
CC       {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8L9J7};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8L9J7}.
CC   -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC       {ECO:0000305}.
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DR   EMBL; CM000762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DKJ4; -.
DR   SMR; P0DKJ4; -.
DR   STRING; 4558.Sb03g024250.1; -.
DR   EnsemblPlants; KXG32676; KXG32676; SORBI_3003G182800.
DR   EnsemblPlants; KXG32677; KXG32677; SORBI_3003G182800.
DR   Gramene; KXG32676; KXG32676; SORBI_3003G182800.
DR   Gramene; KXG32677; KXG32677; SORBI_3003G182800.
DR   eggNOG; KOG1623; Eukaryota.
DR   OMA; VMSINIF; -.
DR   OrthoDB; 1116261at2759; -.
DR   Proteomes; UP000000768; Chromosome 3.
DR   ExpressionAtlas; P0DKJ4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR   InterPro; IPR004316; SWEET_sugar_transpr.
DR   Pfam; PF03083; MtN3_slv; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..243
FT                   /note="Bidirectional sugar transporter SWEET2a"
FT                   /id="PRO_0000434109"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        58..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..89
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        90..110
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        118..138
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..145
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        146..166
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        180..200
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        203..223
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        224..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          24..111
FT                   /note="MtN3/slv 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          147..230
FT                   /note="MtN3/slv 2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   243 AA;  26824 MW;  870BFE3169EBD4CF CRC64;
     MDWAAPALTS FVADSSYRHL CCYGAGIAGN VFAFVLFISP LPTFKRIVRN GSTEQFSAMP
     YIYSLLNCLI CMWYGLPFVS YGVVLVATVN SIGAVFQLAY TAVFIAFADA KQRLKVSALL
     AAVFVVFGLI VFVSLALLDH PTRQMFVGYL SVASLIFMFA SPLSIINLVI RTKSVEYMPF
     YLSLSMFLMS ASFFGYGVLL NDFFIYIPNG IGTILGIIQL VLYAYFRKGS SEEAKLPLLV
     THT