ID   SX11A_XENLA             Reviewed;         382 AA.
AC   Q91731; Q9PSW8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Transcription factor Sox-11-A;
DE            Short=xSox-11;
DE   AltName: Full=XLS13A;
GN   Name=sox11-a; Synonyms=sox11;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Oocyte;
RX   PubMed=8765746; DOI=10.1016/0167-4781(96)00091-7;
RA   Miyata S., Miyashita K., Hosoyama Y.;
RT   "SRY-related genes in Xenopus oocytes.";
RL   Biochim. Biophys. Acta 1308:23-27(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP   STAGE.
RC   TISSUE=Ovary;
RX   PubMed=9332350; DOI=10.1016/s0378-1119(97)00242-4;
RA   Hiraoka Y., Komatsu N., Sakai Y., Ogawa M., Shiozawa M., Aiso S.;
RT   "XLS13A and XLS13B: SRY-related genes of Xenopus laevis.";
RL   Gene 197:65-71(1997).
RN   [3]
RP   FUNCTION, INTERACTION WITH NLK.2, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=12047350; DOI=10.1046/j.1365-2443.2002.00536.x;
RA   Hyodo-Miura J., Urushiyama S., Nagai S., Nishita M., Ueno N., Shibuya H.;
RT   "Involvement of NLK and Sox11 in neural induction in Xenopus development.";
RL   Genes Cells 7:487-496(2002).
CC   -!- FUNCTION: Transcription factor that binds to the DNA sequence 5'-
CC       AACAAT-3' (PubMed:9332350). Acts as a transcriptional activator (By
CC       similarity). Plays a role together with nlk in neural induction during
CC       early embryogenesis (PubMed:12047350). {ECO:0000250|UniProtKB:Q7M6Y2,
CC       ECO:0000269|PubMed:12047350, ECO:0000269|PubMed:9332350}.
CC   -!- SUBUNIT: Interacts with nlk.2. {ECO:0000269|PubMed:12047350}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Expressed in unfertilized eggs but not in early
CC       embryos up to stage 13. Localized to the nervous system at the end of
CC       neurulation, and restricted to the central nervous system, eye and head
CC       neural crest cells by the early tadpole stages. In adults, expressed
CC       throughout the ovary, and also in the testis, kidney, brain and small
CC       intestine. {ECO:0000269|PubMed:12047350, ECO:0000269|PubMed:8765746,
CC       ECO:0000269|PubMed:9332350}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       {ECO:0000269|PubMed:9332350}.
CC   -!- INDUCTION: By chrd. {ECO:0000269|PubMed:12047350}.
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DR   EMBL; D86076; BAA13006.1; -; mRNA.
DR   EMBL; D83650; BAA22778.1; -; mRNA.
DR   PIR; S72169; S72169.
DR   RefSeq; NP_001135834.1; NM_001142362.1.
DR   AlphaFoldDB; Q91731; -.
DR   SMR; Q91731; -.
DR   GeneID; 100216330; -.
DR   KEGG; xla:100216330; -.
DR   CTD; 100216330; -.
DR   Xenbase; XB-GENE-6252061; sox11.L.
DR   OrthoDB; 1186233at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 100216330; Expressed in gastrula and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029551; SOX-11.
DR   InterPro; IPR017386; SOX-12/11/4.
DR   PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Transcription factor Sox-11-A"
FT                   /id="PRO_0000048753"
FT   DNA_BIND        47..115
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        31
FT                   /note="S -> P (in Ref. 2; BAA22778)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        98
FT                   /note="R -> E (in Ref. 1; BAA13006)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        304
FT                   /note="A -> G (in Ref. 2; BAA22778)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   382 AA;  42732 MW;  E83AB1CD91955E84 CRC64;
     MVQRADMDSS QHTEPSTDTE EGEFMACSPV SLDESDPDWC KTATGHIKRP MNAFMVWSKI
     ERRKIMEQSP DMHNAEISKR LGKRWKMLND SEKIPFIREA ERLRLKHMAD YPDYKYRPRK
     KPKVDPSASS KPPALTQSPE KSPKSRSAGR KCPKLKPSHS GSGSKSLSIK SEYSGGSDEY
     VFGSPKASGK AAAAAVKCVF MDEDEEEEEE EEDDEEEEDE LQIRIKQEED DEPLRQYNVA
     KVPASPTLSS SSAESVEGAS MYEDIRNGTR LYYNFKNITK QSTIPQATIT LAPRPAPTTT
     SPAASHELLF DLSLNFTQQN PQLPDPNSGN VSLSLVDKDL DSCSEGSLGS HFDFPDYCTP
     ELSEMIAGDW LEANFSDLVF TY