SX11B_XENLA
ID SX11B_XENLA Reviewed; 374 AA.
AC P40650; Q6NRN8; Q9PSW7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transcription factor Sox-11-B;
DE AltName: Full=Transcription factor Sox-13;
DE Short=xSox-13;
DE AltName: Full=XLS13B;
GN Name=sox11-b; Synonyms=sox11, sox13;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Ovary;
RX PubMed=9332350; DOI=10.1016/s0378-1119(97)00242-4;
RA Hiraoka Y., Komatsu N., Sakai Y., Ogawa M., Shiozawa M., Aiso S.;
RT "XLS13A and XLS13B: SRY-related genes of Xenopus laevis.";
RL Gene 197:65-71(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 56-109.
RC TISSUE=Oocyte;
RX PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT "A conserved family of genes related to the testis determining gene, SRY.";
RL Nucleic Acids Res. 20:2887-2887(1992).
RN [4]
RP FUNCTION, INTERACTION WITH NLK.2, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12047350; DOI=10.1046/j.1365-2443.2002.00536.x;
RA Hyodo-Miura J., Urushiyama S., Nagai S., Nishita M., Ueno N., Shibuya H.;
RT "Involvement of NLK and Sox11 in neural induction in Xenopus development.";
RL Genes Cells 7:487-496(2002).
CC -!- FUNCTION: Transcription factor that binds to the DNA sequence 5'-
CC AACAAT-3' (PubMed:9332350). Acts as a transcriptional activator (By
CC similarity). Plays a role together with nlk in neural induction during
CC early embryogenesis (PubMed:12047350). {ECO:0000250|UniProtKB:Q7M6Y2,
CC ECO:0000269|PubMed:12047350, ECO:0000269|PubMed:9332350}.
CC -!- SUBUNIT: Interacts with nlk.2. {ECO:0000269|PubMed:12047350}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed in unfertilized eggs but not in early
CC embryos up to stage 13. Localized to the nervous system at the end of
CC neurulation, and restricted to the central nervous system, eye and head
CC neural crest cells by the early tadpole stages. In adults, expressed
CC throughout the ovary, and also in the testis, kidney, brain and small
CC intestine. {ECO:0000269|PubMed:12047350, ECO:0000269|PubMed:9332350}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:9332350}.
CC -!- INDUCTION: By chrd. {ECO:0000269|PubMed:12047350}.
CC -!- CAUTION: Was originally termed sox-13. {ECO:0000305|PubMed:1614875}.
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DR EMBL; D87209; BAA22779.1; -; mRNA.
DR EMBL; BC070707; AAH70707.1; -; mRNA.
DR EMBL; X65656; CAA46607.1; -; mRNA.
DR PIR; S22948; S22948.
DR RefSeq; NP_001084325.1; NM_001090856.1.
DR AlphaFoldDB; P40650; -.
DR SMR; P40650; -.
DR DNASU; 399440; -.
DR GeneID; 399440; -.
DR KEGG; xla:399440; -.
DR CTD; 399440; -.
DR Xenbase; XB-GENE-483422; sox11.S.
DR OrthoDB; 1186233at2759; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 399440; Expressed in gastrula and 14 other tissues.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029551; SOX-11.
DR InterPro; IPR017386; SOX-12/11/4.
DR PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..374
FT /note="Transcription factor Sox-11-B"
FT /id="PRO_0000048778"
FT DNA_BIND 45..113
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 199
FT /note="D -> DE (in Ref. 1; BAA22779)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 41964 MW; DA49CE5B62EEAF28 CRC64;
MVQRADMDSS QHTEPDTEEG EFMACSPAAL DESDPDWCKT ATGHIKRPMN AFMVWSKIER
RKIMEQSPDM HNAEISKRLG KRWKMLNDSE KIPFIREAER LRLKHMADYP DYKYRPRKKP
KVDPTASKSP TLAQSPEKSP KSRSAGKKCP KLKPSHSGNS SKSLSIKSEY GVGGDYVFGS
PKSSGKAAVM KCVFMDEDDE EEEEDEEEEE DELQIRIKQE EDDESLRLYN VAKVPASPTL
SSSSAESVEG ASMYEDIRNG TRLYYNFKNI TKQSTIPQAT ITLAPRPLLA TTSPAGSHEL
LFDLSLNFTQ QNPQLPDPNS GNVSLSLVDK DLDSCSEGSL GSHFDFPDYC TPELSEMIAG
DWLEANFSDL VFTY
