SX17A_XENTR
ID SX17A_XENTR Reviewed; 383 AA.
AC Q8AWH3;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcription factor Sox-17-alpha {ECO:0000250|UniProtKB:Q3KQ35};
DE Short=Sox17alpha {ECO:0000312|EMBL:AAT71996.1};
DE Short=tSox17alpha {ECO:0000303|PubMed:12508233};
GN Name=sox17a; Synonyms=sox17 {ECO:0000312|EMBL:CAJ82986.1};
GN ORFNames=TNeu118d15.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN76329.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Gastrula {ECO:0000269|PubMed:12508233};
RX PubMed=12508233; DOI=10.1002/dvdy.10201;
RA D'Souza A., Lee M., Taverner N., Mason J., Carruthers S., Smith J.C.,
RA Amaya E., Papalopulu N., Zorn A.M.;
RT "Molecular components of the endoderm specification pathway in Xenopus
RT tropicalis.";
RL Dev. Dyn. 226:118-127(2003).
RN [2] {ECO:0000312|EMBL:AAT71996.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAT71996.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:CAJ82986.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAT71996.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud {ECO:0000312|EMBL:AAH74527.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription activator. Binds to the DNA sequence 5'-AACAAT-
CC 3'. All of the sox17 proteins are required for embryonic endoderm
CC development and gastrulation movements, and show some redundancy in
CC function. In addition, the sox17 proteins have distinct but overlapping
CC roles in later gut development. Acts downstream of vegt-signaling in
CC endoderm differentiation to induce a range of endodermal genes both
CC directly (including endodermin and dhh/chh) and indirectly. Also
CC represses wnt-responsive genes to inhibit wnt/beta-catenin signaling
CC (By similarity). {ECO:0000250|UniProtKB:Q3KQ35,
CC ECO:0000250|UniProtKB:Q90ZH9}.
CC -!- SUBUNIT: Interacts (via C-terminus) with ctnnb1/beta-catenin (via
CC Armadillo repeats); this interaction is required for inhibition of wnt-
CC signaling. {ECO:0000250|UniProtKB:Q3KQ35}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3KQ35,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the deep and superficial
CC endoderm during gastrulation. During neural and early tail bud stages,
CC expression declines significantly in the anterior endoderm, except in
CC the endoderm behind the cement gland. Strong expression persists in the
CC endoderm posterior to the liver diverticulum until late tail bud stage.
CC By late tailbud, expression is undetectable in most of the endoderm but
CC is maintained in the presumptive gall bladder region and the extreme
CC posterior region. In addition, expressed in endothelial cells in the
CC head and along the flank of the embryo. {ECO:0000269|PubMed:12508233}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:Q9H6I2}.
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DR EMBL; AY157635; AAN76329.1; -; mRNA.
DR EMBL; AC148408; AAT71996.1; -; Genomic_DNA.
DR EMBL; CR848309; CAJ82986.1; -; mRNA.
DR EMBL; BC074527; AAH74527.1; -; mRNA.
DR RefSeq; NP_989425.1; NM_204094.1.
DR AlphaFoldDB; Q8AWH3; -.
DR SMR; Q8AWH3; -.
DR STRING; 8364.ENSXETP00000053697; -.
DR PaxDb; Q8AWH3; -.
DR DNASU; 395066; -.
DR Ensembl; ENSXETT00000053697; ENSXETP00000053697; ENSXETG00000026438.
DR GeneID; 395066; -.
DR KEGG; xtr:395066; -.
DR CTD; 395066; -.
DR Xenbase; XB-GENE-484295; sox17a.
DR eggNOG; KOG0527; Eukaryota.
DR HOGENOM; CLU_044994_0_0_1; -.
DR InParanoid; Q8AWH3; -.
DR OMA; CDAQGLF; -.
DR OrthoDB; 1042753at2759; -.
DR PhylomeDB; Q8AWH3; -.
DR Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000026438; Expressed in gastrula and 22 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008013; F:beta-catenin binding; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; IEA:Ensembl.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; ISS:UniProtKB.
DR GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0070121; P:Kupffer's vesicle development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0060215; P:primitive hemopoiesis; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Gastrulation; Nucleus;
KW Reference proteome; Transcription; Transcription regulation;
KW Wnt signaling pathway.
FT CHAIN 1..383
FT /note="Transcription factor Sox-17-alpha"
FT /id="PRO_0000376052"
FT DOMAIN 267..382
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 61..129
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..337
FT /note="Required for transcriptional activity and
FT interaction with ctnnb1"
FT /evidence="ECO:0000250|UniProtKB:Q3KQ35"
FT MOTIF 331..339
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:Q9H6I2"
SQ SEQUENCE 383 AA; 42826 MW; BE7CC77153C8AAC7 CRC64;
MSSPDGGYAS DDQNQGKCSV PIMMTGLGQC QWAEPMNSLG EGKLKSDAGS ANSRGKAEAR
IRRPMNAFMV WAKDERKRLA QQNPDLHNAE LSKMLGKSWK ALTLAEKRPF VEEAERLRVQ
HMQDHPNYKY RPRRRKQVKR MKRADTGFMH MAEPPESAVL GTDGRMCLES FSLGYHEQTY
PHSQLPQGSH YREPQAMAPH YDGYSLPTPE SSPLDLAEAD PVFFTSPPQD ECQMMPYSYN
ASYTHQQNSG ASMLVRQMPQ AEQMGQGSPV QGMMGCQSSP QMYYGQMYLP GSARHHQLPQ
AGQNSPPPEA QQMGRADHIQ QVDMLAEVDR TEFEQYLSYV AKSDLGMHYH GQESVVPTAD
NGPISSVLSD ASTAVYYCNY PSA
